ArticleFEBS open bio2016
MafB deficiency accelerates the development of obesity in mice.
Article in FEBS open bio, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- MAFB regulates hematopoietic stem cell proliferation and maintenance.Scientific reports · 2025Article
- MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites.Journal of obesity · 2025Article
- MAFB in Macrophages Regulates Prostaglandin E2-Mediated Lipid Mediator Class Switch through ALOX15 in Ischemic Acute Kidney Injury.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Genome-wide association study (GWAS) identified PCOS susceptibility variants and replicates reported risk variants.Archives of gynecology and obstetrics · 2024Article
- Androgen-regulatediScience · 2022Article
- Prediction and Experimental Verification of a Hierarchical Transcription Factor Regulatory Network of Porcine Myoglobin (Mb).Animals : an open access journal from MDPI · 2021Article
- Radiation inducible MafB gene is required for thymic regeneration.Scientific reports · 2021Article
- Unraveling the molecular heterogeneity in type 2 diabetes: a potential subtype discovery followed by metabolic modeling.BMC medical genomics · 2020Article
- An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition.International journal of molecular sciences · 2020Article
- Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model.Experimental animals · 2020Article
- Role of MafB in macrophages.Experimental animals · 2020Review
- MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition.Molecular and cellular biology · 2019Article
- Mice harboring an MCTO mutation exhibit renal failure resembling nephropathy in human patients.Experimental animals · 2019Article
- MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α CellsMolecular and cellular biology · 2018Article
- MAFB mediates the therapeutic effect of sleeve gastrectomy for obese diabetes mellitus by activation of FXR expression.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- MafB is a critical regulator of complement component C1q.Nature communications · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MafB, a transcription factor expressed selectively in macrophages, has important roles in some macrophage-related diseases, especially in atherosclerosis. In this study, we investigated the mechanism by which hematopoietic-specific MafB deficiency induces the development of obesity. Wild-type and hematopoietic cell-specific Mafb-deficient mice were fed a high-fat diet for 10 weeks. The Mafb-deficient mice exhibited higher body weights and faster rates of body weight increase than control mice. The Mafb-deficient mice also had a higher percentage of body fat than the wild-type mice, due to increased adipocyte size and serum cholesterol levels. Reverse transcription-PCR analysis showed a reduction in apoptosis inhibitor of macrophage (AIM) in Mafb-deficient adipose tissue. AIM is known as an inhibitor of lipogenesis in adipocytes and is expressed in adipose tissue macrophages. Collectively, our data suggest that Mafb deficiency in hematopoietic cells accelerates the development of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.