ReviewNature and science of sleep2016
The role of sleep in bipolar disorder.
Review in Nature and science of sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Boulevard of broken rhythms: A systematic review and meta-analysis on the relationship between sleep disturbances and suicidal behavior in bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Sleep abnormalities in bipolar disorders across mood phases: A systematic review and meta-analysis.Sleep medicine reviews · 2025Pooled it
- Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review.Molecular psychiatry · 2018Pooled it
- Sleep Disturbance, Irritability, and Response to Lurasidone Treatment in Children and Adolescents with Bipolar Depression.Current neuropharmacology · 2023Trial
- When the Clock Shifts: A Comprehensive Review of Daylight-Saving Time (DST), Circadian Disruption, and Neuropsychological Risk in Chronic Mental Illness.Brain sciences · 2026Review
- The Relationship Between Emotional Eating Behavior and Internet Addiction in Junior High School Students: A Cross-Sectional Study.Nutrients · 2026Article
- Addressing Stress and Rhythm Dysregulation among Health Workers in the Post-Pandemic Context: An Italian Study and a Proposal for a Preventive Psychoeducational Intervention.Clinical practice and epidemiology in mental health : CP & EMH · 2026Article
- The Relationship Between Sleep Quality and Prodromal Symptoms in Euthymic Patients with Bipolar Disorder.Noro psikiyatri arsivi · 2026Article
- Sleep Disturbances Among Adult Patients with Mood Disorders: A Saudi Cross-Sectional Study.Nature and science of sleep · 2026Article
- A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus.Frontiers in neuroscience · 2026Article
- Unobtrusive inference of diurnal rhythms from smartphone data.NPJ digital medicine · 2025Review
- Evaluation of sleep quality in patients diagnosed with bipolar disorder and major depression during remission period.World journal of psychiatry · 2025Article
- Multimodal Sleep Measurement and Alignment Analysis in Outpatients With Major Depressive Episode: Observational Study.JMIR mHealth and uHealth · 2025Observational
- Self-assessment and rest-activity rhythm monitoring for effective bipolar disorder management: a longitudinal actigraphy study.International journal of bipolar disorders · 2025Article
- Sleep quality in bipolar disorder: A comparative study of treatment with lithium and valproic acid.World journal of psychiatry · 2025Article
- Sleep duration as a mediator of the association between caffeine intake and mood symptoms: An intensive longitudinal study of young adults with and without bipolar spectrum disorders.Chronobiology international · 2025Article
- Screen time and manic symptoms in early adolescents: prospective findings from the Adolescent Brain Cognitive Development Study.Social psychiatry and psychiatric epidemiology · 2025Article
- Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders.Biomedicines · 2025Review
- Unobtrusive inference of circadian rhythms from smartphone data.medRxiv : the preprint server for health sciences · 2025Article
- Uncovering hidden depression: the critical role of depression screening in sleep disorders at U.S. sleep centers.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C) functioning and sleep-wake homeostasis (process S) on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder. A convergence of evidence suggests that sleep problems in bipolar disorder result from dysregulation across both process C and process S systems. Biomarkers of depressive episodes include heightened fragmentation of rapid eye movement (REM) sleep, reduced REM latency, increased REM density, and a greater percentage of awakenings, while biomarkers of manic episodes include reduced REM latency, greater percentage of stage I sleep, increased REM density, discontinuous sleep patterns, shortened total sleep time, and a greater time awake in bed. These findings highlight the importance of targeting novel treatments for sleep disturbance in bipolar disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.