ArticleHippokratia
The platelet-to-lymphocyte ratio as an inflammation marker in non-dipper hypertensive patients.
Article in Hippokratia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Meta-analysis of differences in neutrophil to lymphocyte ratio between hypertensive and non-hypertensive individuals.BMC cardiovascular disorders · 2023Pooled it
- Mean platelet volume is independently associated with systolic and diastolic blood pressure: a retrospective cross-sectional study.BMC cardiovascular disorders · 2026Article
- Association of Inflammatory-Hematological Biomarkers with Hypertension and Related Comorbidities.Journal of clinical medicine · 2026Article
- Analysis of inflammatory markers in patients with abnormal circadian rhythm of blood pressure.Archives of medical science : AMS · 2026Article
- Association between systemic inflammation markers and blood pressure among children and adolescents: National Health and Nutrition Examination Survey.Pediatric research · 2025Article
- Relationships between Easily Available Biomarkers and Non-Dipper Blood Pressure Pattern in Patients with Stable Coronary Artery Disease.Life (Basel, Switzerland) · 2023Article
- Fatty Acid Levels and Their Inflammatory Metabolites Are Associated with the Nondipping Status and Risk of Obstructive Sleep Apnea Syndrome in Stroke Patients.Biomedicines · 2022Article
- Platelet to lymphocyte ratio as a predictive biomarker of liver fibrosis (on elastography) in patients with hepatitis C virus (HCV)-related liver disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Diclofenac - induced hepatotoxicity: Low dose of omega-3 fatty acids have more protective effects.Toxicology reports · 2018Article
- Diagnostic validity of hematologic parameters in evaluation of massive pulmonary embolism.Journal of clinical laboratory analysis · 2017Article
- The platelet-to-lymphocyte ratio as an indirect outcome predictor in primary hypertension: a retrospective study.Porto biomedical journalArticle
- Kolaviron Diminishes Diclofenac-Induced Liver and Kidney Toxicity in Wistar Rats Via Suppressing Inflammatory Events, Upregulating Antioxidant Defenses, and Improving Hematological Indices.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-dipper hypertensive patients have a higher risk of cardiovascular disease (CVD) than dipper hypertensive patients. Inflammation plays an important role in the pathogenesis and progression of CVD. This study aimed to determine the relationship between the platelet-to-lymphocyte ratio (PLR), and dipper and non-dipper hypertension. MATERIALS AND
methodsThis prospective study included 199 consecutive patients that were diagnosed with primary hypertension. According to ambulatory blood pressure monitoring measurements, non-dipper and dipper group were determined. PLR was determined based on the platelet count and lymphocyte count in the complete blood count.
resultsThe non-dipper group included 103 patients (74 females and 29 males; mean age: 52.37 ± 10.7 years) and the dipper group included 96 patients (65 females and 31 males; mean age: 48.40 ± 11.1 years). Mean systolic blood pressure was significantly higher in the non-dipper group than in the dipper group (124 ± 15.1 mmHg versus 120 ± 11.2 mmHg, p =0.032) and the median PLR was significantly higher in the non-dipper group than in the dipper group [132.15 (range: 69.64-400) versus 117.0 (range: 53.52-192.26), p = 0.001], whereas the mean white blood cell count (6.86 ± 1.43 × 10³/ μL versus 7.24 ± 1.26 × 10³/μL, p =0.046) and median lymphocyte count [2.09 (range: 0.95-3.92) × 10³/μL versus 2.24 (range: 0.97-3.98) × 10³/μL, p =0.001) were significantly lower in the non-dipper group.
conclusionMedian PLR was significantly higher in the non-dipper hypertensive patients than in the dipper hypertensive patients. We think this finding further supports the role of an increase in inflammatory response in non-dipper hypertension. Hippokratia 2015; 19 (2):114-118.
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Identifiers
27418758PMC4938100W2513059536What OpenQuestion holds
Registered trials
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