Evidence map›Paper›PMID 27418577›Full record

GuidelineClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016

Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society.

Andre C Kalil, Mark L Metersky, Michael Klompas, John Muscedere, Daniel A Sweeney, Lucy B Palmer, Lena M Napolitano, Naomi P O'Grady, John G Bartlett, Jordi Carratalà and 10 more

Erratum issued 15 registry-linked trialsOpen access · bronzeAbstract readPractice Guideline
In one paragraph

Guideline in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 15 registered trials, which are not on this map. Cited by 1,653 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,653citing papers in PubMed, 6 pooled it
238.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03159078 phase3unknown statusnot on this mapstarted 2017, after this paper: background citation

Polymyxin B Monotherapy Versus Polymyxin B-Carbapenem Combination Therapy in Critically Ill Patients With Multi-drug Resistant Gram-negative Infection: A Prospective, Parallel-Group, Double-Blind, Randomized Controlled Study

TypeinterventionalSponsorUniversity of Puerto RicoRan2017 to 2019Enrolled40ConditionsTrauma, Resistant Infection, Critical IllnessArmsPolymyxin B
NCT03332225 phase2completednot on this mapstarted 2017, after this paper: background citation

A Personalized Randomized Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis

TypeinterventionalSponsorHellenic Institute for the Study of SepsisRan2017 to 2019Enrolled36ConditionsSepsis, Macrophage Activation SyndromeArmsAnakinra, Recombinant human interferon-gamma, Placebo
NCT03515031 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Open Randomized Controlled Clinical Trial Comparing Oxygen Therapy by High Flow Nasal Cannulae and by Venturi Mask in the Treatment of Acute Respiratory Failure Due to Severe Pneumonia (Hi Flow Oxygen vs Venturi Mask In Pneumonia)

TypeinterventionalSponsorPapa Giovanni XXIII HospitalRan2023 to 2026Enrolled150ConditionsRespiratory Insufficiency, PneumoniaArmsHigh Flow Nasal Cannula Oxygenation, Venturi Mask Oxygenation
NCT03682081 nacompletednot on this mapstarted 2020, after this paper: background citation

Impact of Novel Rehabilitative Approaches for Dysphagia in Patients With Alzheimer's Disease and Related Dementias

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2020 to 2025Enrolled76ConditionsDementia, Dysphagia, Alzheimer DiseaseArmsIsometric tongue strengthening facilitated by Iowa Oral Performance Instrument (IOPI), Biotene Oral Balance Gel
NCT03749226 phase2 / phase3terminatednot on this mapstarted 2019, after this paper: background citation

Efficacy, Safety and Pharmacokinetics Profile of Nebulized Aztreonam Lysine (AZLI) for Prevention of Gram Negative Pneumonia in Heavily Colonized Mechanically Ventilated Patients

TypeinterventionalSponsorHospital Universitari Joan XXIII de Tarragona.Ran2019 to 2019Enrolled9ConditionsVentilator Associated Pneumonia, Prevention, Respiratory Infection OtherArmsAztreonam lysine, Aerogen Solo, CombiHaler
NCT04153682 nacompletednot on this mapstarted 2020, after this paper: background citation

Impact of a Strategy Combining the Rapid Polymerase Chain Reaction Platform FilmArray® and the Intervention of an Antimicrobial Stewardship Team in Hospital-acquired Pneumonia : a Randomized Controlled Trial.

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2020 to 2023Enrolled116ConditionsHospital-acquired PneumoniaArmsRapid Diagnostic Testing, Antimicrobial stewardship
NCT04396522 completednot on this mapstarted 2019, after this paper: background citation

Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia

TypeobservationalSponsorChang Gung Memorial HospitalRan2019 to 2023Enrolled194ConditionsPneumoniaArmsnoninvasively Bio-electrical Impedance Analysis (BIA)
NCT04438187 nacompletednot on this mapstarted 2021, after this paper: background citation

Trial of Antimicrobial Restraint in Presumed Pneumonia

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2021 to 2022Enrolled186ConditionsHealthcare-Associated Pneumonia, SepsisArmsantimicrobial initiation
NCT04457817 terminatednot on this mapstarted 2020, after this paper: background citation

CRI and Continuous Assessment of Hemodynamic Compensation to Guide Fluid and Pressor Management in Severely Ill Patients With COVID-19

TypeobservationalSponsorUniversity of Colorado, DenverRan2020 to 2021Enrolled16ConditionsCOVIDArmsCRI
NCT04840940 unknown statusnot on this mapstarted 2020, after this paper: background citation

Presepsin as an Early Biomarker for Ventilator-associated Pneumonia (VAP) Diagnosis in COVID-19 Patients: a Prospective Double Blind Observational Study

TypeobservationalSponsorSan Luigi Gonzaga HospitalRan2020 to 2021Enrolled50ConditionsVentilator Associated Pneumonia, Covid19
NCT05833412 unknown statusnot on this mapstarted 2023, after this paper: background citation

Clinical Study to Improve the Quality of Care in Critically Ill Patients With Suspected Sepsis Through Early Molecular Diagnosis .

Typeobservational_patient_registrySponsorAlejandro Rodriguez Oviedo , MDRan2023 to 2024Enrolled120ConditionsSepsis, Molecular DiagnosisArmsSepticyte Rapid ®, FilmArray® blood culture identification (BCID2®)
NCT06288724 unknown statusnot on this mapstarted 2024, after this paper: background citation

Potentially MOdifiable Factors To ImproVe Outcomes of Mechanically Ventilated Patients in ICUs in a Low-income Country: Rationale and Protocol for a Registry-embedded Prospective Observational Study

Typeobservational_patient_registrySponsorNat Intensive Care Surveillance - MORURan2024 to 2024Enrolled625ConditionsCritical Illness, Invasive Mechanical Ventilation, ICU Mortality, Developing Countries
NCT06650384 phase2 / phase3completednot on this mapstarted 2024, after this paper: background citation

Evaluation of the Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid on the Occurrence and Severity of Colistin-Induced Nephrotoxicity in Critically Ill Patients

TypeinterventionalSponsorAin Shams UniversityRan2024 to 2026Enrolled180ConditionsNephrotoxicityArmsAddition of sachets of N-acetyl cysteine 1200 mg twice/day to the maintenance dose of colistin, Addition of Alpha-lipoic acid 600mg twice daily to the maintenance dose of colistin
NCT06912906 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Comparison of Two Strategies to Allow Mechanical Ventilation Separation Using Biphasic Airway Pressure Ventilation Without Any Synchronization (BIPAP) or Pressure Support Ventilation (PSV): a Randomized Feasibility Trial

TypeinterventionalSponsorUniversity of Lausanne HospitalsRan2025 to 2027Enrolled84ConditionsMechanical Ventilation WeaningArmsBIPAPasynchro: byphaisc positive pressure modality without any synchronisation
NCT07354425 completednot on this mapstarted 2022, after this paper: background citation

Pneumococcal Community-Acquired Pneumonia Requiring Hospitalization Among Colombian Adults (Pneumo-CAP Colombia)

Typeobservational_patient_registrySponsorUniversidad de la SabanaRan2022 to 2025Enrolled688ConditionsCommunity Acquired Pneumonia (CAP), Pneumococcal Pneumonia
3 · Its place in the literature

Who cites it

1,653 citing papers in PubMed, 6 syntheses or guidelines pooled it, 3,817 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Extracorporeal COCritical care (London, England) · 2026
    Trial
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  14. Article
  15. Article
  16. Outcomes of concomitantAnnals of medicine · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Clinical Impact of the BIOFIRE® FILMARRAY® Pneumonia Panel in the Veterans Affairs Healthcare System: A Difference-in-Differences Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Observational

1,593 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 18 institutions in 5 countries.

Andre C KalilDepartment of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha.
Mark L MeterskyDivision of Pulmonary and Critical Care Medicine, University of Connecticut School of Medicine, Farmington.
Michael KlompasBrigham and Women's Hospital and Harvard Medical School Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
John MuscedereDepartment of Medicine, Critical Care Program, Queens University, Kingston, Ontario, Canada.
Daniel A SweeneyDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego.
Lucy B PalmerDepartment of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, State University of New York at Stony Brook.
Lena M NapolitanoDepartment of Surgery, Division of Trauma, Critical Care and Emergency Surgery, University of Michigan, Ann Arbor.
Naomi P O'GradyDepartment of Critical Care Medicine, National Institutes of Health, Bethesda.
John G BartlettJohns Hopkins University School of Medicine, Baltimore, Maryland.
Jordi CarratalàDepartment of Infectious Diseases, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute, Spanish Network for Research in Infectious Diseases, University of Barcelona, Spain.
Ali A El SolhDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, Veterans Affairs Western New York Healthcare System, New York.
Santiago EwigThoraxzentrum Ruhrgebiet, Department of Respiratory and Infectious Diseases, EVK Herne and Augusta-Kranken-Anstalt Bochum, Germany.
Paul D FeyDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
Thomas M FileSumma Health System, Akron, Ohio.
Marcos I RestrepoDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, South Texas Veterans Health Care System and University of Texas Health Science Center at San Antonio.
Jason A RobertsBurns, Trauma and Critical Care Research Centre, The University of Queensland Royal Brisbane and Women's Hospital, Queensland.
Grant W WatererSchool of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Peggy CruseLibrary and Knowledge Services, National Jewish Health, Denver, Colorado.
Shandra L KnightLibrary and Knowledge Services, National Jewish Health, Denver, Colorado.
Jan L BrozekDepartment of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
National Jewish Health · USUniversity of Nebraska Medical Center · USAugusta-Kranken-Anstalt · DEBrigham and Women's Hospital · USInstitut d'Investigació Biomédica de Bellvitge · ESJohns Hopkins University · USMcMaster University · CAMichigan Medicine · USNational Institutes of Health Clinical Center · USQueen's University · CAState University of New York · USSumma Health System · USThe University of Texas Health Science Center at San Antonio · USUniversity of California System · USUniversity of Connecticut · USUniversity of Queensland · AUUniversity of Western Australia · AUVA Western New York Healthcare System · US

Funding

Effect of macrolides as immunomodulators in patients with sepsis and pneumoniaK23HL096054 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RESTREPO, MARCOS I. · 2010 to 2014
$689k
NHLBI NIH HHS K23 HL096054
6 · The paper itself

Abstract

It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.These guidelines are intended for use by healthcare professionals who care for patients at risk for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), including specialists in infectious diseases, pulmonary diseases, critical care, and surgeons, anesthesiologists, hospitalists, and any clinicians and healthcare providers caring for hospitalized patients with nosocomial pneumonia. The panel's recommendations for the diagnosis and treatment of HAP and VAP are based upon evidence derived from topic-specific systematic literature reviews.

Indexed as

AdultAnti-Bacterial AgentsBacteriological TechniquesCross InfectionDrug Resistance, Multiple, BacterialHumansPneumonia, BacterialPneumonia, Ventilator-AssociatedUnited StatesAnti-Bacterial Agents

Identifiers

PMID27418577
PMCPMC4981759
OpenAlexW2473016454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 9 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.