ReviewNature reviews. Neurology2016
The Glasgow Outcome Scale - 40 years of application and refinement.
Review in Nature reviews. Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 207 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury: a Prospective Randomized Controlled Trial.
The Interaction Between Cognitive Reserve and Neuropsychological Variables, Variables Related to Psychological Well-being and Health Care Usage in Relation to Long-term Outcome After Stroke or Traumatic Brain Injury
Who cites it
207 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Functional recovery in older adults following mild traumatic brain injury: a systematic review.European geriatric medicine · 2026Pooled it
- Red blood cell transfusion in neurocritical patients: an updated systematic review and meta-analysis.BMC anesthesiology · 2026Pooled it
- Red blood cell transfusion strategy in traumatic brain injury patients: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Liberal vs. restrictive transfusion strategies for acute brain injury: a systematic review and frequentist-Bayesian meta-analysis.Intensive care medicine · 2025Pooled it
- Prediction performance of the machine learning model in predicting mortality risk in patients with traumatic brain injuries: a systematic review and meta-analysis.BMC medical informatics and decision making · 2023Pooled it
- The Impact of Invasive Brain Oxygen Pressure Guided Therapy on the Outcome of Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Neurocritical care · 2022Pooled it
- Longer than 2 hours to antibiotics is associated with doubling of mortality in a multinational community-acquired bacterial meningitis cohort.Scientific reports · 2022Pooled it
- Pooled it
- Apolipoprotein E4 Polymorphism and Outcomes from Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis.Journal of neurotrauma · 2021Pooled it
- Minimal Clinically Important Difference of the Functional Status Scale in Pediatric Neurocritical Care Patients: Post Hoc Analysis of a Randomized Controlled Trial.Neurocritical care · 2026Trial
- Impact of Rural Trauma Team Development Education on Prehospital Time, Referral-to-Dispatch Interval, and Neurological and Musculoskeletal Injury Outcomes: Cluster Randomized Controlled Trial.JMIR human factors · 2026Trial
- Long-Term Outcomes and Recovery Trajectories in Out-of-Hospital Cardiac Arrest: A 2-Year Follow-Up of the Randomized Clinical TTM2 Trial.JAMA neurology · 2026Trial
- Cardiac output-guided vs. mean arterial pressure-guided hemodynamic management in craniotomy patients with cardiovascular disease: a randomized trial.Scientific reports · 2026Trial
- Partial oral antibiotic treatment for bacterial brain abscess: an open-label randomized non-inferiority trial (ORAL).Trials · 2021Trial
- Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents.Journal of neurotrauma · 2021Trial
- Hyperbaric oxygen for severe traumatic brain injury: a randomized trial.The Journal of international medical research · 2020Trial
- Monitoring Outcome after Hospital-Presenting Milder Spectrum Pediatric Traumatic Brain Injury Using the Glasgow Outcome Scale-Extended, Pediatric Revision.Journal of neurotrauma · 2020Trial
- Glasgow Outcome Scale Measures and Impact on Analysis and Results of a Randomized Clinical Trial of Severe Traumatic Brain Injury.Journal of neurotrauma · 2019Trial
- Admission ionised calcium disturbances and adverse outcomes in paediatric major trauma: a UK multicentre retrospective cohort study.BMJ open · 2026Article
- Effectiveness and Safety of Minimally Invasive Surgery for Infratentorial Hemorrhages: A Meta-Analysis of Clinical and Technical Outcomes.Asian journal of neurosurgery · 2026Review
147 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The Glasgow Outcome Scale (GOS) was first published in 1975 by Bryan Jennett and Michael Bond. With over 4,000 citations to the original paper, it is the most highly cited outcome measure in studies of brain injury and the second most-cited paper in clinical neurosurgery. The original GOS and the subsequently developed extended GOS (GOSE) are recommended by several national bodies as the outcome measure for major trauma and for head injury. The enduring appeal of the GOS is linked to its simplicity, short administration time, reliability and validity, stability, flexibility of administration (face-to-face, over the telephone and by post), cost-free availability and ease of access. These benefits apply to other derivatives of the scale, including the Glasgow Outcome at Discharge Scale (GODS) and the GOS paediatric revision. The GOS was devised to provide an overview of outcome and to focus on social recovery. Since the initial development of the GOS, there has been an increasing focus on the multidimensional nature of outcome after head injury. This Review charts the development of the GOS, its refinement and usage over the past 40 years, and considers its current and future roles in developing an understanding of brain injury.
Indexed as
Identifiers
27418377What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.