ArticleScientific reports2016
Wound healing profiles of hyperopic-small incision lenticule extraction (SMILE).
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Femtosecond laser-assisted stromal keratophakia for keratoconus: A systemic review and meta-analysis.International ophthalmology · 2021Pooled it
- Comparison of tear proteomic and neuromediator profiles changes between small incision lenticule extraction (SMILE) and femtosecond laser-assisted in-situ keratomileusis (LASIK).Journal of advanced research · 2021Trial
- Hyperopic keratorefractive lenticule extraction.Journal of cataract and refractive surgery · 2026Review
- Changes in the effective optical zone following hyperopic keratorefractive lenticule extraction.Annals of medicine · 2025Article
- Randomized controlled trial on corneal denervation, neuroinflammation and ocular surface in corneal lenticule extraction for advanced refractive correction (CLEAR) and small incision lenticule extraction (SMILE).Eye and vision (London, England) · 2025Article
- Corneal subbasal nerve plexus reinnervation and stromal cell morphology with different cap thicknesses in small incision lenticule extraction.Eye and vision (London, England) · 2024Article
- Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thickness.BMC ophthalmology · 2023Article
- Corneal neuromediator profiles following laser refractive surgery.Neural regeneration research · 2021Review
- Intraocular pressure changes and corneal biomechanics after hyperopic small-incision lenticule extraction.BMC ophthalmology · 2020Article
- Tissue Responses and Wound Healing following Laser Scleral Microporation for Presbyopia Therapy.Translational vision science & technology · 2020Article
- Corneal remodelling and topography following biological inlay implantation with combined crosslinking in a rabbit model.Scientific reports · 2019Article
- An Experimental Study of Femto-Laser in Assisting Xenograft Acellular Cornea Matrix Lens Transplantation.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Higher-Order-Aberrations Following Hyperopia Treatment: Small Incision Lenticule Extraction, Laser-Assisted In Situ Keratomileusis and Lenticule Implantation.Translational vision science & technology · 2018Article
- Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model.PloS one · 2018Article
- Mechanisms of Optical Regression Following Corneal Laser Refractive Surgery: Epithelial and Stromal Responses.Medical hypothesis, discovery & innovation ophthalmology journal · 2018Review
- Corneal thickening and central flattening induced by femtosecond laser hyperopic-shaped intrastromal lenticule implantation.International ophthalmology · 2017Article
- Corneal Clarity and Visual Outcomes after Small-Incision Lenticule Extraction and Comparison to Femtosecond Laser-Assisted In Situ Keratomileusis.Journal of ophthalmology · 2017Article
- Role of percent peripheral tissue ablated on refractive outcomes following hyperopic LASIK.PloS one · 2017Article
- Early postoperative changes in corneal densitometry after SMILE with 120-μm and 130-μm cap thickness: a comparative study.Advances in ophthalmology practice and researchArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Refractive surgical treatment of hyperopia still remains a challenge for refractive surgeons. A new nomogram of small incision lenticule extraction (SMILE) procedure has recently been developed for the treatment of hyperopia. In the present study, we aimed to evaluate the wound healing and inflammatory responses of this new nomogram (hyperopic-SMILE), and compared them to those of hyperopic-laser-assisted in situ keratomileusis (LASIK), using a rabbit model. A total of 26 rabbits were used, and slit lamp biomicroscopy, autorefractor/keratometer, intraocular pressure measurement, anterior segment optical coherence tomography, corneal topography, and in vivo confocal microscopy examinations were performed during the study period of 4 weeks. The corneas were then harvested and subject to immunofluorescence of markers for inflammation (CD11b), wound healing (fibronectin) and keratocyte response (HSP47). The lenticule ultrastructual changes were also analyzed by transmission electron microscopy. Out results showed that hyperopic-SMILE effectively steepened the cornea. Compared to hyperopic-LASIK, hyperopic-SMILE had less postoperative wound healing response and stromal interface reaction, especially in higher refractive correction. However, compared to myopic-SMILE, hyperopic-SMILE resulted in more central deranged collagen fibrils. These results provide more perspective into this new treatment option for hyperopia, and evidence for future laser nomogram modification.
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