Evidence map›Paper›PMID 27418294›Full record

ReviewAdvances in colloid and interface science2017

Bulk and nanoscale polypeptide based polyelectrolyte complexes.

Amanda B Marciel, Eun Ji Chung, Blair K Brettmann, Lorraine Leon

Open access · greenAbstract readReview
In one paragraph

Review in Advances in colloid and interface science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Stimuli-responsive polypeptide nanogels for trypsin inhibition.Beilstein journal of nanotechnology · 2022
    Article
  6. Article
  7. Article
  8. Self-organizing motors divide active liquid droplets.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amanda B MarcielInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Eun Ji ChungInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, United States; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, United States.
Blair K BrettmannInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Lorraine LeonInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637, United States. Electronic address: lorraineleon@uchicago.edu.
University of Chicago · USUniversity of Southern California · US

Funding

Multimodal Peptide Amphiphile Micelles for AtherosclerosisR00HL124279 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUNG, EUN JI PAIGE · 2016 to 2018
$747k
Multimodal Peptide Amphiphile Micelles for AtherosclerosisK99HL124279 · NHLBI · UNIVERSITY OF CHICAGO · PI CHUNG, EUN JI PAIGE · 2015 to 2016
$180k
NHLBI NIH HHS K99 HL124279NHLBI NIH HHS R00 HL124279
6 · The paper itself

Abstract

Polyelectrolyte complexes (PECs) formed using polypeptides have great potential for developing new self-assembled materials, in particular for the development of drug and gene delivery vehicles. This review discusses the latest advancements in PECs formed using polypeptides as the polyanion and/or the polycation in both polyelectrolyte complexes that form bulk materials and block copolymer complexes that form nanoscale assemblies such as PEC micelles and other self-assembled structures. We highlight the importance of secondary structure formation between homogeneous polypeptide complexes, which, unlike PECs formed using other polymers, introduces additional intermolecular interactions in the form of hydrogen bonding, which may influence precipitation over coacervation. However, we still include heterogeneous complexes consisting of polypeptides and other polymers such as nucleic acids, sugars, and other synthetic polyelectrolytes. Special attention is given to complexes formed using nucleic acids as polyanions and polypeptides as polycations and their potential for delivery applications.

Indexed as

CoacervatesMicellePolyelectrolytesPolypeptidesSelf-assembly

Identifiers

PMID27418294
PMCPMC5205580
OpenAlexW2470287045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.