Evidence map›Paper›PMID 27418254›Full record

ArticleGenome biology2016

Mendelian randomization in (epi)genetic epidemiology: an effective tool to be handled with care.

Antti Latvala, Miina Ollikainen

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Antti LatvalaFinnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00290, Helsinki, Finland.
Miina OllikainenFinnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00290, Helsinki, Finland. miina.ollikainen@helsinki.fi.ORCID 0000-0003-3661-7400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A study examining blood lipid traits takes epigenomics approaches to the next level by using carefully performed Mendelian randomization to assess causality rather than simply reporting associations.See related research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1000-6.

Indexed as

Molecular EpidemiologyEpigenesis, GeneticHumansLipidsPhenotypeRandom AllocationLipids

Identifiers

PMID27418254
PMCPMC4944517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.