Trial reportJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus2016
A pilot randomized clinical trial of intermittent occlusion therapy liquid crystal glasses versus traditional patching for treatment of moderate unilateral amblyopia.
Trial report in Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Interventions for improving adherence to amblyopia treatments in children.The Cochrane database of systematic reviews · 2025Pooled it
- Amblyopia Preferred Practice Pattern.Ophthalmology · 2023Guideline
- Randomized clinical trial of streaming dichoptic movies versus patching for treatment of amblyopia in children aged 3 to 7 years.Scientific reports · 2022Trial
- Alternative Flicker Glass: A New Anti-Suppression Approach to the Treatment of Anisometropic Amblyopia.Ophthalmic research · 2021Trial
- Baseline and Clinical Factors Associated with Response to Amblyopia Treatment in a Randomized Clinical Trial.Optometry and vision science : official publication of the American Academy of Optometry · 2020Trial
- Recent advances in strabismus.Indian journal of ophthalmology · 2026Article
- Systematic Review and Meta-Analysis of RCTs on Efficacy of Conventional vs. Emerging Treatments for Amblyopia.Life (Basel, Switzerland) · 2026Review
- Assessing Previous Strategies and Presenting a Novel Smart Glasses to Enhance Adherence to Amblyopia Therapy in Children.Patient preference and adherence · 2025Review
- Amblyopia and the whole child.Progress in retinal and eye research · 2023Review
- Effectiveness of Laser Refractive Surgery to Address Anisometropic Amblyogenic Refractive Error in Children: A Report by the American Academy of Ophthalmology.Ophthalmology · 2022Article
- Monitoring of wearing and occlusion times with smart shutter glasses-A proof of concept.PloS one · 2022Article
- Management of amblyopia in pediatric patients: Current insights.Eye (London, England) · 2022Review
- Recent Advances in Screening and Treatment for Amblyopia.Ophthalmology and therapy · 2021Review
- A Randomized Clinical Trial Comparing Eyetronix Flicker Glass and Patching for Treatment of Amblyopia in Children Reveals Similar Improvements in Vision.Frontiers in neuroscience · 2021Article
- Context-sensitive smart glasses monitoring wear position and activity for therapy compliance-A proof of concept.PloS one · 2021Article
- Article
- [Treatment monitoring and innovations in amblyopia treatment].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- Current Management of Childhood Amblyopia.Korean journal of ophthalmology : KJO · 2019Review
- Simplified updates on the pathophysiology and recent developments in the treatment of amblyopia: A review.Indian journal of ophthalmology · 2019Review
- Feasibility of monitoring compliance with intermittent occlusion therapy glasses for amblyopia treatment.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo compare the effectiveness of intermittent occlusion therapy (IO therapy) using liquid crystal glasses and continuous occlusion therapy using traditional adhesive patches for treating amblyopia.
methodsChildren 3-8 years of age with previously untreated, moderate, unilateral amblyopia (visual acuity of 20/40 to 20/100 in the amblyopic eye) were enrolled in this randomized controlled trial. Amblyopia was associated with strabismus, anisometropia, or both. All subjects had worn any optimal refractive correction for at least 12 weeks without improvement. Subjects were randomized into two treatment groups: a 4-hour IO therapy group with liquid crystal glasses (Amblyz), set at 30-second opaque/transparent intervals (occluded 50% of wear time), and a 2-hour continuous patching group (occluded 100% of wear time). For each patient, visual acuity was measured using ATS-HOTV before and after 12 weeks of treatment.
resultsData from 34 patients were available for analysis. Amblyopic eye visual acuity improvement from baseline was 0.15 ± 0.12 logMAR (95% CI, 0.09-0.15) in the IO therapy group (n = 19) and 0.15 ± 0.11 logMAR (95% CI, 0.1-0.15) in the patching group (n = 15). In both groups improvement was significant, but the difference between groups was not (P = 0.73). No adverse effects were reported.
conclusionsIn this pilot study, IO therapy with liquid crystal glasses is not inferior to adhesive patching and is a promising alternative treatment for children 3-8 years of age with moderate amblyopia.
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Registered trials
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