Evidence map›Paper›PMID 27418089›Full record

ArticleKidney international2016

APOL1 risk variants and death among African American hemodialysis patients: survival of the fittest?

Teresa K Chen, Michelle M Estrella

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. APOL1 Gene Kidney Risk Variants and Cardiovascular Disease: Getting to the Heart of the Matter.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Teresa K ChenDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Michelle M EstrellaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: mestrel1@jhmi.edu.

Funding

Biomarkers of Kidney Injury to Predict AKI Onset and Progression in HIV InfectionR01DK103574 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ESTRELLA, MICHELLE M · 2015 to 2020
$3.4M
NIDDK NIH HHS R01 DK103574
6 · The paper itself

Abstract

Recent studies have focused on associations of the APOL1 risk variants with outcomes beyond kidney disease, including cardiovascular disease and mortality. Ma and colleagues now expand on this growing but contradicting body of work. Their analysis of a prevalent cohort of African American hemodialysis patients shows that the risk variants are associated with a survival benefit among nondiabetics. Whether this simply reflects a healthier status at hemodialysis initiation among those carrying 2 risk variants or whether these variants truly confer a survival advantage is unclear.

Indexed as

Black or African AmericanApolipoproteinsGenetic Predisposition to DiseaseHumansLipoproteins, HDLRenal DialysisApolipoproteinsLipoproteins, HDL

Identifiers

PMID27418089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.