Evidence map›Paper›PMID 27418084›Full record

ArticleKidney international2016

LAPping up dead cells to prevent lupus nephritis: a novel role for noncanonical autophagy in autoimmunity.

Jeremy S Leventhal, Michael J Ross

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Mold and Human Health: a Reality Check.Clinical reviews in allergy & immunology · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jeremy S LeventhalDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Renal Division, James J. Peters Bronx Veterans Affairs Medical Center, Bronx, New York, USA. Electronic address: Jeremy.leventhal@mssm.edu.
Michael J RossDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Renal Division, James J. Peters Bronx Veterans Affairs Medical Center, Bronx, New York, USA.
James J. Peters VA Medical Center · US

Funding

The Role of Autophagy in LPS-Induced Acute Kidney InjuryK08DK090217 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEVENTHAL, JEREMY SETH · 2013 to 2017
$755k
NIDDK NIH HHS K08 DK090217
6 · The paper itself

Abstract

The mechanisms underlying the development of systemic lupus erythematosus and lupus nephritis remain poorly understood. A recent study demonstrates that deficiencies in the immune system's ability to degrade scavenged dead cells via noncanonical autophagy is sufficient to break immune tolerance and produce features commonly seen in lupus, including circulating autoantibodies, inflammatory cytokines, and nephritis. This work provides a possible mechanism for the association of polymorphisms in autophagy genes with the risk of lupus.

Indexed as

AutoantibodiesAutoimmunityAutophagyHumansLupus Erythematosus, SystemicLupus NephritisAutoantibodies

Identifiers

PMID27418084
OpenAlexW2467112797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.