Evidence map›Paper›PMID 27417982›Full record

Trial reportContemporary clinical trials2016

Open-label randomized trial of titrated disease management for patients with hypertension: Study design and baseline sample characteristics.

George L Jackson, Morris Weinberger, Miriam A Kirshner, Karen M Stechuchak, Stephanie D Melnyk, Hayden B Bosworth, Cynthia J Coffman, Brian Neelon, Courtney Van Houtven, Pamela W Gentry and 9 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01390272 (Randomized Trial of Titrated Disease Management for Patients With Hypertension), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01390272 nacompletednot on this map

Randomized Trial of Titrated Disease Management for Patients With Hypertension

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2012 to 2016Enrolled385ConditionsHypertensionArmsBooster/ low resource, Medium/Level 1 resource intensity, High/Level 2 resource intensity
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Enrollment and Retention of Men and Women in Health Services Research and Development Trials.Women's health issues : official publication of the Jacobs Institute of Women's Health · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

George L JacksonCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Medicine, Division of General Internal Medicine, Duke University, Durham, NC 27710, USA. Electronic address: george.l.jackson@duke.edu.
Morris WeinbergerCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Health Policy and Management, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Miriam A KirshnerCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
Karen M StechuchakCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
Stephanie D MelnykCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
Hayden B BosworthCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Medicine, Division of General Internal Medicine, Duke University, Durham, NC 27710, USA.
Cynthia J CoffmanCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Biostatistics & Bioinformatics, Duke University, Durham, NC 27710, USA.
Brian NeelonDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Courtney Van HoutvenCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Medicine, Division of General Internal Medicine, Duke University, Durham, NC 27710, USA.
Pamela W GentryCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Medicine, Division of General Internal Medicine, Duke University, Durham, NC 27710, USA.
Isis J MorrisCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
Cynthia M RoseCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Medicine, Division of General Internal Medicine, Duke University, Durham, NC 27710, USA.
Jennifer P TaylorCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
Carrie L MayCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
Byungjoo HanCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
Christi WainwrightCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
Aviel AlkonCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Medicine, Division of General Internal Medicine, Duke University, Durham, NC 27710, USA.
Lesa PowellCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
David EdelmanCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA; Department of Medicine, Division of General Internal Medicine, Duke University, Durham, NC 27710, USA.
Duke University · USMedical University of South Carolina · USUniversity of North Carolina at Chapel Hill · US

Funding

Randomized Trial of Titrated Disease Management for Patients with HypertensionI01HX000537 · VA · DURHAM VA MEDICAL CENTER · PI EDELMAN, DAVID, JACKSON, GEORGE L. · 2013 to 2015
–
HSRD VA I01 HX000537HSRD VA RCS 08-027
6 · The paper itself

Abstract

Despite the availability of efficacious treatments, only half of patients with hypertension achieve adequate blood pressure (BP) control. This paper describes the protocol and baseline subject characteristics of a 2-arm, 18-month randomized clinical trial of titrated disease management (TDM) for patients with pharmaceutically-treated hypertension for whom systolic blood pressure (SBP) is not controlled (≥140mmHg for non-diabetic or ≥130mmHg for diabetic patients). The trial is being conducted among patients of four clinic locations associated with a Veterans Affairs Medical Center. An intervention arm has a TDM strategy in which patients' hypertension control at baseline, 6, and 12months determines the resource intensity of disease management. Intensity levels include: a low-intensity strategy utilizing a licensed practical nurse to provide bi-monthly, non-tailored behavioral support calls to patients whose SBP comes under control; medium-intensity strategy utilizing a registered nurse to provide monthly tailored behavioral support telephone calls plus home BP monitoring; and high-intensity strategy utilizing a pharmacist to provide monthly tailored behavioral support telephone calls, home BP monitoring, and pharmacist-directed medication management. Control arm patients receive the low-intensity strategy regardless of BP control. The primary outcome is SBP. There are 385 randomized (192 intervention; 193 control) veterans that are predominately older (mean age 63.5years) men (92.5%). 61.8% are African American, and the mean baseline SBP for all subjects is 143.6mmHg. This trial will determine if a disease management program that is titrated by matching the intensity of resources to patients' BP control leads to superior outcomes compared to a low-intensity management strategy.

Indexed as

Disease ManagementResearch DesignAdolescentAdultAgedAge FactorsAntihypertensive AgentsBehavior TherapyBlack or African AmericanBlood Pressure Monitoring, AmbulatoryExerciseFemaleHealth BehaviorHumansHypertensionMaleAntihypertensive AgentsHypertensionRandomized controlled trialVeterans

Identifiers

PMID27417982
PMCPMC5035600
OpenAlexW2471052884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.