Evidence map›Paper›PMID 27417821›Full record

ReviewHealthcare (Basel, Switzerland)2015

Perinatal Maternal Mental Health, Fetal Programming and Child Development.

Andrew J Lewis, Emma Austin, Rebecca Knapp, Tina Vaiano, Megan Galbally

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Healthcare (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 9 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 9 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Systematic Review: Antipsychotic Medication in Pregnancy and Neurodevelopmental Outcomes in Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Fetal Body Composition and Organ Volume Trajectories in Association With Maternal Perceived Stress or Depressive Symptoms in the Fetal 3D Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrew J LewisSchool of Psychology, Faculty of Health, Deakin University, Melbourne 3102, Australia. eeaust002@myacu.edu.au.
Emma AustinSchool of Psychology, Faculty of Health, Deakin University, Melbourne 3102, Australia. eeaust002@myacu.edu.au.
Rebecca KnappSchool of Psychology, Faculty of Health, Deakin University, Melbourne 3102, Australia. rknap@deakin.edu.au.
Tina VaianoSchool of Psychology, Faculty of Health, Deakin University, Melbourne 3102, Australia. MGalbally@mercy.com.au.
Megan GalballyPerinatal Mental Health Unit, Mercy Hospital for Women, Heidelberg 3084, Australia. MGalbally@mercy.com.au.
Deakin University · AUMercy Hospital for Women · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal mental disorders over pregnancy show a clear influence on child development. This review is focused on the possible mechanisms by which maternal mental disorders influence fetal development via programming effects. This field is complex since mental health symptoms during pregnancy vary in type, timing and severity and maternal psychological distress is often accompanied by higher rates of smoking, alcohol use, poor diet and lifestyle. Studies are now beginning to examine fetal programming mechanisms, originally identified within the DOHaD framework, to examine how maternal mental disorders impact fetal development. Such mechanisms include hormonal priming effects such as elevated maternal glucocorticoids, alteration of placental function and perfusion, and epigenetic mechanisms. To date, mostly high prevalence mental disorders such as depression and anxiety have been investigated, but few studies employ diagnostic measures, and there is very little research examining the impact of maternal mental disorders such as schizophrenia, bipolar disorder, eating disorders and personality disorders on fetal development. The next wave of longitudinal studies need to focus on specific hypotheses driven by plausible biological mechanisms for fetal programming and follow children for a sufficient period in order to examine the early manifestations of developmental vulnerability. Intervention studies can then be targeted to altering these mechanisms of intergenerational transmission once identified.

Indexed as

child temperamentcortisolepigeneticsfetal programminggrowthmental health in pregnancyperinatal depression and anxietyplacenta

Identifiers

PMID27417821
PMCPMC4934640
OpenAlexW2177182457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.