ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2016
Cerebral Hemodynamics in the Elderly: A Transcranial Doppler Study in the Einstein Aging Study Cohort.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis.The Journal of clinical psychiatry · 2018Trial
- Bedside transcranial Doppler as a diagnostic bridge for suspected intracranial hypertension after traumatic brain injury surgery: A case report.Surgical neurology international · 2026Article
- Modeling Pressure-Dependent Wave and Vessel Compliance in the Brain Following Middle Cerebral Artery Occlusion.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Sex differences in middle cerebral artery reactivity and hemodynamics independent from changes in systemic arterial stiffness in Sprague-Dawley rats.Physiological reports · 2025Article
- Age-specific sex-differences in cerebral blood flow velocity in relation to haemoglobin levels.European stroke journal · 2024Article
- Review
- Pulsatile microvascular cerebral blood flow waveforms change with intracranial compliance and age.Neurophotonics · 2024Article
- The effect of relative cerebral hyperperfusion during cardiac surgery with cardiopulmonary bypass to delayed neurocognitive recovery.Perfusion · 2023Article
- Normative cerebral microvascular blood flow waveform morphology assessed with diffuse correlation spectroscopy.Biomedical optics express · 2023Article
- Normative Cerebral Hemodynamics in Middle-aged and Older Adults Using 4D Flow MRI: Initial Analysis of Vascular Aging.Radiology · 2023Article
- Article
- Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Cerebral Autoregulation in Ischemic Stroke: From Pathophysiology to Clinical Concepts.Brain sciences · 2021Review
- Age, sex, and the vascular contributors to cerebral pulsatility and pulsatile damping.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Sleep, brain vascular health and ageing.GeroScience · 2020Review
- Preoperative transcranial Doppler and cerebral oximetry as predictors of delirium following valvular heart surgery: a case-control study.Journal of clinical monitoring and computing · 2020Observational
- Cerebral arterial time constant calculated from the middle and posterior cerebral arteries in healthy subjects.Journal of clinical monitoring and computing · 2019Article
- The Protective Role of Regular Aerobic Exercise on Vascular Function with Aging.Current opinion in physiology · 2019Article
- Cerebral Hemodynamics in Sleep Apnea and Actigraphy-Determined Sleep Duration in a Sample of the Hispanic Community Health Study/ Study of Latinos.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Effect of healthy aging and sex on middle cerebral artery blood velocity dynamics during moderate-intensity exercise.American journal of physiology. Heart and circulatory physiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesWe sought to describe the relationship between age, sex, and race/ethnicity with transcranial Doppler hemodynamic characteristics from major intracerebral arterial segments in a large elderly population with varying demographics.
methodsWe analyzed 369 stroke-free participants aged 70 years and older from the Einstein Aging Study. Single-gate, nonimaging transcranial Doppler sonography, a noninvasive sonographic technique that assesses real-time cerebrovascular hemodynamics, was used to interrogate 9 cerebral arterial segments. Individual Doppler spectra and cerebral blood flow velocities were acquired, and the pulsatility index and resistive index were calculated by the device's automated waveform-tracking function. Multiple linear regression models were used to examine the independent associations of age, sex, and race/ethnicity with transcranial Doppler measures, adjusting for hypertension, history of myocardial infarction or revascularization, and history of diabetes.
resultsAmong enrolled participants, 303 individuals had at least 1 vessel insonated (mean age [SD], 80 [6] years; 63% women; 58% white; and 32% black). With age, transcranial Doppler measures of mean blood flow velocity were significantly decreased in the basilar artery (P = .001) and posterior cerebral artery (right, P = .003; left, P = .02). Pulsatility indices increased in the left middle cerebral artery (P = .01) and left anterior cerebral artery (P = .03), and the resistive index was increased in the left middle cerebral artery (P = .007) with age. Women had higher pulsatility and resistive indices compared to men in several vessels.
conclusionsWe report a decreased mean blood flow velocity and weakly increased arterial pulsatility and resistance with aging in a large elderly stroke-free population. These referential trends in cerebrovascular hemodynamics may carry important implications in vascular diseases associated with advanced age, increased risk of cerebrovascular disease, cognitive decline, and dementia.
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