ArticleDoklady. Biochemistry and biophysics2016
Native structure of rat liver immune proteasomes.
Article in Doklady. Biochemistry and biophysics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Relationship Estimation of Cell Mobility Proteins Level with Processes of Proteolysis and Lymphogenic Metastasis in Breast Cancer.Doklady. Biochemistry and biophysics · 2021Article
- Detection of active proteasome structures in brain extracts: proteasome features of August rat brain with violations in monoamine metabolism.Oncotarget · 2017Article
- Role of proteasomes in non-specific immune response of marine annelids.Doklady. Biochemistry and biophysics · 2016Article
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4 authors at 1 institution in 1 country.
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Abstract
Native structure of active forms of rat liver immune proteasomes has been studied by two-dimensional electrophoresis method modified for analysis of unpurified protein fractions. The developed method allowed revealing the proteasome immune subunits LMP7 and LMP2 in 20S subparticles and in the structures bound to one or two PA28αβ activators, but not to the PA700 activator, which is involved in the hydrolysis of ubiquitinated proteins. The results obtained indicate the participation of the immune proteasomes in delicate regulatory mechanisms based on the production of biologically active peptides and exclude their participation in processes of crude degradation of "rotated" ubiquitinated proteins.
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