ArticleNeurobiology of learning and memory2017
Persistent increased PKMζ in long-term and remote spatial memory.
Article in Neurobiology of learning and memory, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 67 citations in OpenAlex.
- Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long-Term Active Place Avoidance Memory and "Shadow" Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- PKMζ in the prefrontal cortex alters cocaine cue-induced reinstatement in a sex-specific manner.Psychopharmacology · 2026Article
- Transcriptomic signatures of hippocampal active place avoidance memory maintenance.Frontiers in cellular neuroscience · 2026Article
- BDNF Signaling in Glutamatergic Neurons During Long-Term Potentiation (LTP): A Spatio-Temporal Exploration of Events.Molecular neurobiology · 2025Review
- Persistently increased expression of PKMzeta and unbiased gene expression profiles identify hippocampal molecular traces of a long-term active place avoidance memory and 'shadow' proteins.bioRxiv : the preprint server for biology · 2025Article
- Beyond boundaries: extended temporal flexibility in synaptic tagging and capture.Communications biology · 2025Article
- Amygdala stimulation transforms short-term memory into remote memory by persistent activation of atypical protein kinase C in the anterior cingulate cortex.Neuroscience · 2025Article
- PKMζ drives spatial memory reconsolidation but not maintenance.Frontiers in synaptic neuroscience · 2025Article
- KIBRA anchoring the action of PKMζ maintains the persistence of memory.Science advances · 2024Article
- KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.The Journal of clinical investigation · 2024Article
- Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core.Biology of sex differences · 2023Article
- Karim Nader and the unification of memory erasure: PKMζ inhibition and reconsolidation blockade.Brain research bulletin · 2023Review
- Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKMζ and increased κOR in the hippocampus of female mice.Journal of psychopharmacology (Oxford, England) · 2021Article
- Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage.The European journal of neuroscience · 2021Article
- Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Memory Destabilization and Reconsolidation Dynamically Regulate the PKMζ Maintenance Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Modeling suggests combined-drug treatments for disorders impairing synaptic plasticity via shared signaling pathways.Journal of computational neuroscience · 2021Article
- Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation.Frontiers in computational neuroscience · 2020Article
- Antisense Oligodeoxynucleotide Perfusion Blocks Gene Expression of Synaptic Plasticity-related Proteins without Inducing Compensation in Hippocampal Slices.Bio-protocol · 2019Article
- aPKC in neuronal differentiation, maturation and function.Neuronal signaling · 2019Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
PKMζ is an autonomously active PKC isoform that is thought to maintain both LTP and long-term memory. Whereas persistent increases in PKMζ protein sustain the kinase's action in LTP, the molecular mechanism for the persistent action of PKMζ during long-term memory has not been characterized. PKMζ inhibitors disrupt spatial memory when introduced into the dorsal hippocampus from 1day to 1month after training. Therefore, if the mechanisms of PKMζ's persistent action in LTP maintenance and long-term memory were similar, persistent increases in PKMζ would last for the duration of the memory, far longer than most other learning-induced gene products. Here we find that spatial conditioning by aversive active place avoidance or appetitive radial arm maze induces PKMζ increases in dorsal hippocampus that persist from 1day to 1month, coinciding with the strength and duration of memory retention. Suppressing the increase by intrahippocampal injections of PKMζ-antisense oligodeoxynucleotides prevents the formation of long-term memory. Thus, similar to LTP maintenance, the persistent increase in the amount of autonomously active PKMζ sustains the kinase's action during long-term and remote spatial memory maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.