ReviewChildren (Basel, Switzerland)2015
Controversies in the Mechanism of Total Parenteral Nutrition Induced Pathology.
Review in Children (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Antioxidant Supplementation ReducesCurrent developments in nutrition · 2026Article
- Longitudinal Plasma Metabolomics by GC-MS and LC-MS During Total Parenteral Nutrition After Gastrointestinal Surgery.Metabolites · 2026Article
- Mechanistic Analysis of Fisetin in Liver Diseases and Its Potential Therapeutic Application in IFALD-A Review of In Vitro and In Vivo Studies.Nutrients · 2025Review
- Parenteral Nutrition, Inflammatory Bowel Disease, and Gut Barrier: An Intricate Plot.Nutrients · 2024Review
- Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery.Current drug targets · 2024Review
- Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations.Biomedicines · 2023Review
- Review
- Beyond lipids: Novel mechanisms for parenteral nutrition-associated liver disease.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2022Review
- Association Between Drug Treatments and the Incidence of Liver Injury in Hospitalized Patients With COVID-19.Frontiers in pharmacology · 2022Article
- The administration of hepatocyte growth factor prevents total parenteral nutrition-induced hepatocellular injury in a rat model.Pediatric surgery international · 2021Article
- Failure of primary closure predicts prolonged length of stay in gastroschisis patients.Pediatric surgery international · 2021Article
- Risk of Liver Injury Associated with Intravenous Lipid Emulsions: A Prescription Sequence Symmetry Analysis.Frontiers in pharmacology · 2021Article
- Development and validation of an ambulatory piglet model for short bowel syndrome with ileo-colonic anastomosis.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Impaired Gut-Systemic Signaling Drives Total Parenteral Nutrition-Associated Injury.Nutrients · 2020Article
- Ovary removal modifies liver message RNA profiles in single Comb White Leghorn chickens.Poultry science · 2020Article
- Role of Bile Acids and Gut Microbiota in Parenteral Nutrition Associated Injury.Journal of human nutrition (Carson City, Nev.) · 2020Article
- Developing a Novel Ambulatory Total Parenteral Nutrition-Dependent Short Bowel Syndrome Animal Model.The Journal of surgical research · 2019Article
- No Gut No Gain! Enteral Bile Acid Treatment Preserves Gut Growth but Not Parenteral Nutrition-Associated Liver Injury in a Novel Extensive Short Bowel Animal Model.JPEN. Journal of parenteral and enteral nutrition · 2018Article
- Intestinal transplants: review of normal imaging appearance and complications.The British journal of radiology · 2018Review
- Pediatric Intestinal Failure Review.Children (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over 30,000 patients are permanently dependent on Total Parenteral Nutrition (TPN) for survival with several folds higher requiring TPN for a prolonged duration. Unfortunately, it can cause potentially fatal complications. TPN infusion results in impairment of gut mucosal integrity, enhanced inflammation, increased cytokine expression and trans-mucosal bacterial permeation. It also causes endotoxin associated down regulation of bile acid transporters and Parenteral Nutrition Associated Liver Disease (PNALD), which includes steatosis, disrupted glucose metabolism, disrupted lipid metabolism, cholestasis and liver failure. Despite multiple theories, its etiology and pathophysiology remains elusive and is likely multifactorial. An important cause for TPN related pathologies appears to be a disruption in the normal enterohepatic circulation due to a lack of feeding during such therapy. This is further validated by the fact that in clinical settings, once cholestasis sets in, its reversal occurs when a patient is receiving a major portion of calories enterally. There are several other postulated mechanisms including gut bacterial permeation predisposing to endotoxin associated down regulation of bile acid transporters. An additional potential mechanism includes toxicity of the TPN solution itself, such as lipid mediated hepatic toxicity. Prematurity, leading to a poor development of bile acid regulating nuclear receptors and transporters has also been implicated as a causative factor. This review presents the current controversies and research into mechanisms of TPN associated injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.