ReviewChildren (Basel, Switzerland)2015
The Role of Human Milk Immunomodulators in Protecting Against Viral Bronchiolitis and Development of Chronic Wheezing Illness.
Review in Children (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Association between PMInternational journal of environmental research and public health · 2022Pooled it
- Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Increase Child Morbidity in a Semiurban Setting in Ghana: A Secondary Outcome Noninferiority Analysis of the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD Randomized Controlled Trial.The Journal of nutrition · 2020Trial
- MFGM-enriched whey displays antiviral activity against common pediatric virusesFrontiers in nutrition · 2024Article
- Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A.The Journal of experimental medicine · 2023Article
- Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A.bioRxiv : the preprint server for biology · 2023Article
- The burden of viral lower respiratory tract infections during the neonatal period: six-year experience at a tertiary referral hospital.Croatian medical journal · 2022Article
- Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.Nutrients · 2022Article
- The Role of Breastfeeding on Respiratory Outcomes Later in Childhood.Frontiers in pediatrics · 2022Article
- Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis.World journal of clinical pediatrics · 2021Article
- Analysis of SARS-CoV-2 vertical transmission during pregnancy.Nature communications · 2020Article
- Identification of bronchiolitis profiles in Italian children through the application of latent class analysis.Italian journal of pediatrics · 2020Article
- Potential repurposed SARS-CoV-2 (COVID-19) infection drugs.RSC advances · 2020Review
- Article
- Quantitative Longitudinal Inventory of theJournal of proteome research · 2020Article
- Positive association of breastfeeding on respiratory syncytial virus infection in hospitalized infants: a multicenter retrospective study.Clinical and experimental pediatrics · 2020Article
- Review
- Anti-Infective, Anti-Inflammatory, and Immunomodulatory Properties of Breast Milk Factors for the Protection of Infants in the Pandemic From COVID-19.Frontiers in public health · 2020Article
- Association of Breastfeeding and Air Pollution Exposure With Lung Function in Chinese Children.JAMA network open · 2019Article
- Breastfeeding and Respiratory Infections in the First 6 Months of Life: A Case Control Study.Frontiers in pediatrics · 2019Article
- Respiratory syncytial virüs infections in neonates and infants.Turk pediatri arsivi · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infants who are breastfed are at an immunological advantage when compared with formula fed infants, evidenced by decreased incidence of infections and diminished propensity for long term conditions, including chronic wheeze and/or asthma. Exclusive breastfeeding reduces the duration of hospital admission, risk of respiratory failure and requirement for supplemental oxygen in infants hospitalised with bronchiolitis suggesting a potentially protective mechanism. This review examines the evidence and potential pathways for protection by immunomodulatory factors in human milk against the most common viral cause of bronchiolitis, respiratory syncytial virus (RSV), and subsequent recurrent wheeze in infants. Further investigations into the interplay between respiratory virus infections such as RSV and how they affect, and are affected by, human milk immunomodulators is necessary if we are to gain a true understanding of how breastfeeding protects many infants but not all against infections, and how this relates to long-term protection against conditions such as chronic wheezing illness or asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.