ReviewCNS drugs2016
May the Force Be With You: The Light and Dark Sides of the Microbiota-Gut-Brain Axis in Neuropsychiatry.
Review in CNS drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03494725 (Proof-of-Concept "Stress & Anxiety Dampening Effects of Lpc-37"), which is not on this map. Cited by 133 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Proof-of-Concept "Stress & Anxiety Dampening Effects of Lpc-37"
Who cites it
133 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Pooled it
- Fiber intake and fiber intervention in depression and anxiety: a systematic review and meta-analysis of observational studies and randomized controlled trials.Nutrition reviews · 2024Pooled it
- Influential articles in autism and gut microbiota: bibliometric profile and research trends.Frontiers in microbiology · 2024Pooled it
- From gut to brain: unveiling probiotic effects through a neuroimaging perspective-A systematic review of randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Serum plasminogen activator inhibitor-1 levels in patients with major depressive disorder vs. healthy controls: a systematic review and meta-analysis.Trends in psychiatry and psychotherapy · 2023Pooled it
- Pooled it
- Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review.Gut microbes · 2020Pooled it
- Effect of Oral Administration ofInternational journal of environmental research and public health · 2022Trial
- Disturbance in human gut microbiota networks by parasites and its implications in the incidence of depression.Scientific reports · 2020Trial
- Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1Mediators of inflammation · 2020Trial
- Child development, growth and microbiota: follow-up of a randomized education trial in Uganda.Journal of global health · 2019Trial
- Article
- Potential of Saliva in Stroke Patients: A Review.International journal of molecular sciences · 2026Review
- From association to causality: mechanistic pathways linking the gut microbiome to psychiatric disorders.Translational psychiatry · 2026Review
- High-intensity exercise training alters gut microbiota to mitigate the development of experimental autoimmune encephalomyelitis.Scientific reports · 2026Article
- Short-Chain Fatty Acids Regulate Poultry Feed Intake via the Hypothalamus: Receptor-Mediated and Epigenetic Mechanisms.Animals : an open access journal from MDPI · 2026Review
- Article
- A dual pathway intervention of tES and FMT enhances emotion regulation in stressed military personnel.Discover mental health · 2026Review
- Abdominal Ultrasound Stimulation Alleviates Negative Symptoms Through Modulation of Serotonin Signaling and Gut Microbiota in the MK-801 Model of Schizophrenia.Schizophrenia bulletin · 2026Article
- Probiotic Supplementation Modulates FGFR2 and TLR4 Signaling and Attenuates Chronic Neuroinflammation in an Experimental Stroke Model.Neurochemical research · 2026Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the gut microbiota in health and disease is becoming increasingly recognized. The microbiota-gut-brain axis is a bi-directional pathway between the brain and the gastrointestinal system. The bacterial commensals in our gut can signal to the brain through a variety of mechanisms, which are slowly being resolved. These include the vagus nerve, immune mediators and microbial metabolites, which influence central processes such as neurotransmission and behaviour. Dysregulation in the composition of the gut microbiota has been identified in several neuropsychiatric disorders, such as autism, schizophrenia and depression. Moreover, preclinical studies suggest that they may be the driving force behind the behavioural abnormalities observed in these conditions. Understanding how bacterial commensals are involved in regulating brain function may lead to novel strategies for development of microbiota-based therapies for these neuropsychiatric disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.