Evidence map›Paper›PMID 27417220›Full record

ReviewExpert review of clinical immunology2017

Environmental risk factors and their role in the management of atopic dermatitis.

Robert Kantor, Jonathan I Silverberg

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05330637 (Study on the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya, Hainan Province, China.), which is not on this map. Cited by 150 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05330637 unknown statusnot on this mapstarted 2022, after this paper: background citation

Study on the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya, Hainan Province, China.

TypeobservationalSponsorShanghai Jiao Tong University School of MedicineRan2022 to 2025Enrolled800ConditionsAsthma, Allergic Rhinitis, Chronic Obstructive Pulmonary Disease(COPD), Atopic DermatitisArmsClimate and environment in Sanya
3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  6. Pooled it
  7. Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations.International journal of environmental research and public health · 2020
    Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Article
  15. Prenatal PMNature communications · 2026
    Article
  16. Article
  17. Review
  18. Atopic dermatitis.Nature reviews. Disease primers · 2026
    Review
  19. Article
  20. Article

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert Kantora Department of Dermatology , Northwestern University , Chicago , IL , USA.
Jonathan I Silverbergb Departments of Dermatology, Preventive Medicine and Medical Social Sciences , Northwestern University , Chicago , IL , USA.

Funding

Northwestern University Patient-centered Intervention and Engagement TrainingK12HS023011 · AHRQ · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CELLA, DAVID · 2014 to 2018
$3.7M
AHRQ HHS K12 HS023011
6 · The paper itself

Abstract

introductionThe etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors. Areas covered: We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD. Expert commentary: The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

Indexed as

Environmental ExposureAnimalsDermatitis, AtopicFemaleHumansPregnancyPrenatal Exposure Delayed EffectsPrevalenceRisk FactorsUnited Statesallergenatopic dermatitisbacteriaclimateEczemaenvironmentgene-environmentherpeshumidityhygiene hypothesisinflammationirritantlatitudepathogenpollutionprecipitationpregnancyprenatalskin-barriertemperatureultravioletvirus

Identifiers

PMID27417220
PMCPMC5216178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.