ArticleJournal of cognitive neuroscience2016
Startle Habituation and Midfrontal Theta Activity in Parkinson Disease.
Article in Journal of cognitive neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Effect of Traumatic Brain Injury on Sensorimotor Gating.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Diminished preparatory physiological responses in people with dementia: associations with caregiver health and relationship quality.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Amphetamine increases timing variability by degrading prefrontal temporal encoding.Neuropharmacology · 2025Article
- Habituation learning: insights from zebrafish larvae.Frontiers in molecular neuroscience · 2025Review
- Investigating acoustic startle habituation and prepulse inhibition with silent functional MRI and electromyography in young, healthy adults.Frontiers in human neuroscience · 2024Article
- The neurophysiological brain-fingerprint of Parkinson's disease.medRxiv : the preprint server for health sciences · 2023Article
- Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Combined EEG and immersive virtual reality unveil dopaminergic modulation of error monitoring in Parkinson's Disease.NPJ Parkinson's disease · 2023Article
- Impaired proactive cognitive control in Parkinson's disease.Brain communications · 2023Article
- Characterizing neurocognitive impairments in Parkinson's disease with mobile EEG when walking and stepping over obstacles.Brain communications · 2023Article
- Novelty-induced frontal-STN networks in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Defining Specific Cell States of MPTP-Induced Parkinson's Disease by Single-Nucleus RNA Sequencing.International journal of molecular sciences · 2022Article
- Interval timing and midfrontal delta oscillations are impaired in Parkinson's disease patients with freezing of gait.Journal of neurology · 2022Article
- Subcellular Dissection of a Simple Neural Circuit: Functional Domains of the Mauthner-Cell During Habituation.Frontiers in neural circuits · 2021Article
- Approach to Cognitive Impairment in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Habituation of auditory startle reflex is a new sign of minimally conscious state.Brain : a journal of neurology · 2020Article
- Prefrontal D1 Dopamine-Receptor Neurons and Delta Resonance in Interval Timing.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Mid-frontal theta activity is diminished during cognitive control in Parkinson's disease.Neuropsychologia · 2018Article
- Diminished EEG habituation to novel events effectively classifies Parkinson's patients.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- A human prefrontal-subthalamic circuit for cognitive control.Brain : a journal of neurology · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The ability to adapt to aversive stimuli is critical for mental health. Here, we investigate the relationship between habituation to startling stimuli and startle-related activity in medial frontal cortex as measured by EEG in both healthy control participants and patients with Parkinson disease (PD). We report three findings. First, patients with PD exhibited normal initial startle responses but reduced startle habituation relative to demographically matched controls. Second, control participants had midfrontal EEG theta activity in response to startling stimuli, and this activity was attenuated in patients with PD. Finally, startle-related midfrontal theta activity was correlated with the rate of startle habituation. These data indicate that impaired startle habituation in PD is a result of attenuated midfrontal cognitive control signals. Our findings could provide insight into the frontal regulation of startle habituation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.