ArticleJournal of cognitive neuroscience2016
Differential Contributions of Ventral and Dorsal Striatum to Early and Late Phases of Cognitive Set Reconfiguration.
Article in Journal of cognitive neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Efficient and dynamic neural geometry of value and modality encoding in the primate putamen for value-guided behavior.Nature communications · 2025Article
- Adaptive coding of reward in schizophrenia, its change over time and relationship to apathy.Brain : a journal of neurology · 2024Article
- The role of environmental contextual cues in sequence learning: evidence from a virtual maze context.Psychological research · 2024Article
- Parallel learning and cognitive flexibility impairments betweenFrontiers in behavioral neuroscience · 2022Article
- A new era for executive function research: On the transition from centralized to distributed executive functioning.Neuroscience and biobehavioral reviews · 2021Review
- Rules warp feature encoding in decision-making circuits.PLoS biology · 2020Article
- Emergence of abstract rules in the primate brain.Nature reviews. Neuroscience · 2020Review
- Partial integration of the components of value in anterior cingulate cortex.Behavioral neuroscience · 2020Article
- Activity in orbitofrontal neuronal ensembles reflects inhibitory control.The European journal of neuroscience · 2020Article
- Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The neural basis of predictive pursuit.Nature neuroscience · 2020Article
- Cortical and Striatal Circuits in Huntington's Disease.Frontiers in neuroscience · 2020Review
- Tonic exploration governs both flexibility and lapses.PLoS computational biology · 2019Article
- Macaques are risk-averse in a freely moving foraging task.Scientific reports · 2019Article
- Success and failure of controlling the real-time functional magnetic resonance imaging neurofeedback signal are reflected in the striatum.Brain and behavior · 2019Article
- Prefrontal cortex and cognitive control: new insights from human electrophysiology.F1000Research · 2019Review
- Review
- Neural correlates of subjective CS/UCS association in appetitive conditioning.Human brain mapping · 2018Article
- Using a Simple Neural Network to Delineate Some Principles of Distributed Economic Choice.Frontiers in computational neuroscience · 2018Article
- Control without Controllers: Toward a Distributed Neuroscience of Executive Control.Journal of cognitive neuroscience · 2017Review
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2 authors.
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Abstract
Flexible decision-making, a defining feature of human cognition, is typically thought of as a canonical pFC function. Recent work suggests that the striatum may participate as well; however, its role in this process is not well understood. We recorded activity of neurons in both the ventral (VS) and dorsal (DS) striatum while rhesus macaques performed a version of the Wisconsin Card Sorting Test, a classic test of flexibility. Our version of the task involved a trial-and-error phase before monkeys could identify the correct rule on each block. We observed changes in firing rate in both regions when monkeys switched rules. Specifically, VS neurons demonstrated switch-related activity early in the trial-and-error period when the rule needed to be updated, and a portion of these neurons signaled information about the switch context (i.e., whether the switch was intradimensional or extradimensional). Neurons in both VS and DS demonstrated switch-related activity at the end of the trial-and-error period, immediately before the rule was fully established and maintained, but these signals did not carry any information about switch context. We also observed associative learning signals (i.e., specific responses to options associated with rewards in the presentation period before choice) that followed the same pattern as switch signals (early in VS, later in DS). Taken together, these results endorse the idea that the striatum participates directly in cognitive set reconfiguration and suggest that single neurons in the striatum may contribute to a functional handoff from the VS to the DS during reconfiguration processes.
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