ArticleScientific reports2016
Knock out of the PHOSPHATE 2 Gene TaPHO2-A1 Improves Phosphorus Uptake and Grain Yield under Low Phosphorus Conditions in Common Wheat.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Transcription factors in phosphorus utilization: enhancing crop productivity and stress resilience.Planta · 2026Review
- Reinforced Defenses:International journal of molecular sciences · 2025Review
- Genetic dissection for phosphorus uptake and utilization efficiency at seedling stage in wheat (Molecular breeding : new strategies in plant improvement · 2025Article
- Concentration-Dependent N-P Interactions Cause Organ-Specific Responses and Nutrient Allocation in Poplar Seedlings.Plants (Basel, Switzerland) · 2025Article
- From genes to traits: maximizing phosphorus utilization efficiency in crop plants.Frontiers in plant science · 2025Review
- Comprehensive approaches to design efficient gRNA for SDN1-CRISPR/Cas9 genome editing in wheat.Frontiers in genome editing · 2025Article
- Comparative transcriptomic and physiological analyses unravel wheat source root adaptation to phosphorous deficiency.Scientific reports · 2024Article
- Milestones in understanding transport, sensing, and signaling of the plant nutrient phosphorus.The Plant cell · 2024Review
- The importance of genotyping within the climate-smart plant breeding value chain - integrative tools for genetic enhancement programs.Frontiers in plant science · 2024Review
- Article
- Narrowing down molecular targets for improving phosphorus-use efficiency in maize (Zea mays L.).Molecular biology reports · 2022Review
- Wheat genomic study for genetic improvement of traits in China.Science China. Life sciences · 2022Review
- Alfalfa (Medicago sativa L.) pho2 mutant plants hyperaccumulate phosphate.G3 (Bethesda, Md.) · 2022Article
- Present and future prospects for wheat improvement through genome editing and advanced technologies.Plant communications · 2021Review
- Genome-Wide Identification of Wheat ZIP Gene Family and Functional Characterization of theFrontiers in plant science · 2021Article
- Transcriptional, metabolic, physiological and developmental responses of switchgrass to phosphorus limitation.Plant, cell & environment · 2021Article
- Global Analysis of the Genetic Variations in miRNA-Targeted Sites and Their Correlations With Agronomic Traits in Rapeseed.Frontiers in genetics · 2021Article
- An EfficientFrontiers in plant science · 2021Article
- Root Adaptation via Common Genetic Factors Conditioning Tolerance to Multiple Stresses for Crops Cultivated on Acidic Tropical Soils.Frontiers in plant science · 2020Review
- Phosphate acquisition efficiency in wheat is related to root:shoot ratio, strigolactone levels, and PHO2 regulation.Journal of experimental botany · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MiR399 and its target PHOSPHATE2 (PHO2) play pivotal roles in phosphate signaling in plants. Loss of function mutation in PHO2 leads to excessive Pi accumulation in shoots and growth retardation in diploid plants like Arabidopsis thaliana and rice (Oryza sativa). Here we isolated three PHO2 homologous genes TaPHO2-A1, -B1 and -D1 from hexaploid wheat (Triticum aestivum). These TaPHO2 genes all contained miR399-binding sites and were able to be degraded by tae-miR399. TaPHO2-D1 was expressed much more abundantly than TaPHO2-A1 and -B1. The ion beam-induced deletion mutants were used to analyze the effects of TaPHO2s on phosphorus uptake and plant growth. The tapho2-a1, tapho2-b1 and tapho2-d1 mutants all had significant higher leaf Pi concentrations than did the wild type, with tapho2-d1 having the strongest effect, and tapho2-b1 the weakest. Two consecutive field experiments showed that knocking out TaPHO2-D1 reduced plant height and grain yield under both low and high phosphorus conditions. However, knocking out TaPHO2-A1 significantly increased phosphorus uptake and grain yield under low phosphorus conditions, with no adverse effect on grain yield under high phosphorus conditions. Our results indicated that TaPHO2s involved in phosphorus uptake and translocation, and molecular engineering TaPHO2 shows potential in improving wheat yield with less phosphorus fertilizer.
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