SynthesisJournal of perinatology : official journal of the California Perinatal Association2016
Systematic review and meta-analysis of human milk intake and retinopathy of prematurity: a significant update.
Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 93 citations in OpenAlex.
- Impact of Access to Pasteurised Donor Human Milk on Rates of Necrotising Enterocolitis in Neonatal Units in Australia: A Cohort Study.Journal of paediatrics and child health · 2026Article
- Determinants of regression kinetics in observed stage 3 retinopathy of prematurity without plus disease.Eye (London, England) · 2026Article
- Sustaining Breastmilk Expression and Direct Feeding at Breast for Very Low Birth Infants: A Qualitative Exploration of Parental Perspectives.Maternal & child nutrition · 2026Article
- Short outcomes of donor milk and mother's own milk for preterm infants.Pediatric research · 2026Article
- Ten-year changes in risk factors for requiring treatment of retinopathy of prematurity in extremely low birth weight infants: a multicenter study in Tokyo.Japanese journal of ophthalmology · 2026Observational
- Breast Milk Expression Frequency and Production, Na Concentrations and Na:K Ratios in the First 4 Weeks After Preterm Birth.Nutrients · 2026Article
- The Impact of Opt-In versus Opt-Out Consent Process for the Use of Donor Human Milk on Feeding Practice and Growth Pattern in Preterm Neonates.American journal of perinatology · 2026Article
- Review
- Long-term breastfeeding outcomes in very preterm infants: predictors and challenges.Frontiers in pediatrics · 2026Article
- Early Nutritional Patterns and Metabolic Biomarkers Associated with ROP Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Surviving Extremely Low Birth Weight Infants Have a Higher Risk of ROP in Sub-Saharan Africa.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Nutritional Management for Preterm Infants with Common Comorbidities: A Narrative Review.Nutrients · 2025Review
- Impact of Enteral Nutrition on Clinical Outcomes in Very Low Birth Weight Infants in the NICU: A Single-Center Retrospective Cohort Study.Nutrients · 2025Article
- The need for high quality research regarding donor human milk supplementation in moderately-late preterm and early-term infants.Pediatric research · 2025Article
- Oxygen delivery and monitoring in neonatal intensive care units in Mexico in 2011 and in 2023: an observational longitudinal study.BMC nursing · 2024Article
- Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection.BMC ophthalmology · 2024Article
- Monitoring the Use of Human Milk, the Ideal Food for Very Low-Birth-Weight Infants-A Narrative Review.Foods (Basel, Switzerland) · 2024Review
- Early enteral nutrition with exclusive donor milk instead of formula milk affects the time of full enteral feeding for very low birth weight infants.Frontiers in nutrition · 2024Article
- Characterization of exosomal microRNAs in preterm infants fed with breast milk and infant formula.Frontiers in nutrition · 2024Article
- The Effects of Early Enteral and Parental Nutrition on Retinopathy of Prematurity: A Systematic Review.Cureus · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTwo recent meta-analyses have studied the association of exclusive or mainly human milk intake (HMI) on retinopathy of prematurity (ROP). One of these meta-analysis found a protective effect of only or mainly HMI on Severe ROP but not on any stage ROP. However, both these meta-analyses did not find protection from any stage ROP or Severe ROP with any amount of HMI. The objective of this study was to study the association between any amount of HMI and the development of All ROP and Severe ROP in very-low birth weight infants (VLBWI) and extremely low birth weight infants (ELBWI) by systematic review using PRISMA-P guidelines and meta-analysis. STUDY
designExposure, controls and outcomes studied were any amount of HMI vs no HMI and All ROP/Severe ROP in VLBWI/ELBWI. All ROP was defined as all stages of ROP pooled together, and Severe ROP as ⩾stage 3 ROP and ROP requiring intervention. Results and effect sizes are expressed as odds ratio (OR), relative risk (RR), risk difference (RD) and number needed to treat (NNT) with 95% confidence intervals (95% CI). Data sources used were PubMed, MEDLINE, EMBASE, Cochrane Central Register of Clinical Trials, Scopus and CINAHL until 24 April 2015. Extracted data were pooled using a fixed effects model. Heterogeneity was assessed. Sensitivity analysis was performed.
resultsFive hundred nine of 1701 infants who received any amount of HMI developed All ROP vs 310 of 760 infants without HMI developed All ROP with a pooled OR 0.63* (0.51,0.78), RR 0.76* (0.67,0.86) and RD -0.09* (-0.13,-0.05). The NNT with any amount of HMI was 11* (8,20) (*P<0.0001) to prevent one case of All ROP. 204 of 2465 infants who received any amount of HMI developed Severe ROP vs 85 of 764 infants without HMI developed Severe ROP with a pooled OR 0.74* (0.56,0.98), RR 0.77* (0.60,0.98) and RD -0.03* (-0.05,-0.00). The NNT with any amount of HMI was 33* (*P=0.04) to prevent one case of Severe ROP.
conclusionAny amount of HMI is strongly associated with the protection from All ROP and Severe ROP.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.