Evidence map›Paper›PMID 27415011›Full record

ArticleBritish journal of cancer2016

Molecular evidence of viral DNA in non-small cell lung cancer and non-neoplastic lung.

Lary A Robinson, Crystal J Jaing, Christine Pierce Campbell, Anthony Magliocco, Yin Xiong, Genevra Magliocco, James B Thissen, Scott Antonia

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 6 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 6 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Human papillomavirus and lung cancer: an overview and a meta-analysis.Journal of cancer research and clinical oncology · 2019
    Pooled it
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lary A RobinsonDepartment of Thoracic Oncology, Moffitt Cancer Center, Tampa, Florida 33612-9416, USA.
Crystal J JaingPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94559-9698, USA.
Christine Pierce CampbellCenter for Infection Research in Cancer (CIRC), Moffitt Cancer Center, Tampa, Florida 33612-9416, USA.
Anthony MaglioccoDepartment of Pathology, Moffitt Cancer Center, Tampa, Florida 33612-9416, USA.
Yin XiongDepartment of Pathology, Moffitt Cancer Center, Tampa, Florida 33612-9416, USA.
Genevra MaglioccoDepartment of Pathology, Moffitt Cancer Center, Tampa, Florida 33612-9416, USA.
James B ThissenPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94559-9698, USA.
Scott AntoniaDepartment of Thoracic Oncology, Moffitt Cancer Center, Tampa, Florida 33612-9416, USA.
Moffitt Cancer Center · USLawrence Livermore National Laboratory · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

backgroundAlthough ∼20% of human cancers are caused by microorganisms, only suspicion exists for a microbial cause of lung cancer. Potential infectious agents were investigated in non-small cell lung cancer (NSCLC) and non-neoplastic lung.

methodsSeventy NSCLC tumours (33 squamous cell carcinomas, 17 adenocarcinomas, 10 adenocarcinomas with lepidic spread, and 10 oligometastases) and 10 non-neoplastic lung specimens were evaluated for molecular evidence of microorganisms. Tissues were subjected to the Lawrence Livermore Microbial Detection Array, an oncovirus panel of the International Agency for Research on Cancer, and human papillomavirus (HPV) genotyping. Associations were examined between microbial prevalence, clinical characteristics, and p16 and EGFR expression.

resultsRetroviral DNA was observed in 85% squamous cell carcinomas, 47% adenocarcinomas, and 10% adenocarcinomas with lepidic spread. Human papillomavirus DNA was found in 69% of squamous cell carcinomas with 30% containing high-risk HPV types. No significant viral DNA was detected in non-neoplastic lung. Patients with tumours containing viral DNA experienced improved long-term survival compared with patients with viral DNA-negative tumours.

conclusionsMost squamous cell carcinomas and adenocarcinomas contained retroviral DNA and one-third of squamous cell carcinomas contained high-risk HPV DNA. Viral DNA was absent in non-neoplastic lung. Trial results encourage further study of the viral contribution to lung carcinogenesis.

Indexed as

AdenocarcinomaAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCyclin-Dependent Kinase Inhibitor p16DNA, ViralErbB ReceptorsFemaleGenotypeHumansLungLung NeoplasmsMaleMiddle AgedOncogenic VirusesCyclin-Dependent Kinase Inhibitor p16DNA, ViralEGFR protein, humanErbB Receptors

Identifiers

PMID27415011
PMCPMC4985355
OpenAlexW2474562936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.