ArticlePLoS neglected tropical diseases2016
Undiscovered Bat Hosts of Filoviruses.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Temporal and spatial limitations in global surveillance for bat filoviruses and henipaviruses.Biology letters · 2019Pooled it
- Host phylogenetic distance drives trends in virus virulence and transmissibility across the animal-human interface.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Pooled it
- Prioritizing surveillance of Nipah virus in India.PLoS neglected tropical diseases · 2019Pooled it
- Surveillance for Asiatic filoviruses and zoonotic paramyxoviruses at a perceived wildlife-human interface.Emerging microbes & infections · 2026Article
- Predicting unknown mammalian viral hosts with Dynamic Positive-Unlabeled learning.Nature communications · 2026Article
- Article
- Host-virus association databases as tools for understanding viral spillover at varying scales.PLoS neglected tropical diseases · 2026Article
- Serologic evidence of orthomarburgviruses and an orthoebolavirus in frugivorous Malagasy bats.One health outlook · 2025Article
- Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology.Annals of the New York Academy of Sciences · 2025Review
- Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.Cell host & microbe · 2025Article
- Pathogens and planetary change.Nature reviews. Biodiversity · 2025Article
- Genomic characterization of novel bat kobuviruses in Madagascar: Implications for viral evolution and zoonotic risk.PloS one · 2025Article
- Studying bats using a One Health lens: bridging the gap between bat virology and disease ecology.Journal of virology · 2024Review
- Ecological and evolutionary characteristics of anthropogenic roosting ability in bats of the world.iScience · 2024Article
- A tale of endurance: bats, viruses and immune dynamics.Future microbiology · 2024Review
- Robust evidence for bats as reservoir hosts is lacking in most African virus studies: a review and call to optimize sampling and conserve bats.Biology letters · 2023Review
- A species-level trait dataset of bats in Europe and beyond.Scientific data · 2023Article
- Glycosylation and the global virome.Molecular ecology · 2023Article
- Trends in Bacterial Pathogens of Bats: Global Distribution and Knowledge Gaps.Transboundary and emerging diseases · 2023Review
- Traits, phylogeny and host cell receptors predict Ebolavirus host status among African mammals.PLoS neglected tropical diseases · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high biodiversity of potential hosts in temporally dynamic environments of equatorial Africa contributes to sporadic, unpredictable outbreaks that have hampered efforts to identify wild reservoirs for nearly 40 years. Using a machine learning algorithm, generalized boosted regression, we characterize potential filovirus-positive bat species with estimated 87% accuracy. Our model produces two specific outputs with immediate utility for guiding filovirus surveillance in the wild. First, we report a profile of intrinsic traits that discriminates hosts from non-hosts, providing a biological caricature of a filovirus-positive bat species. This profile emphasizes traits describing adult and neonate body sizes and rates of reproductive fitness, as well as species' geographic range overlap with regions of high mammalian diversity. Second, we identify several bat species ranked most likely to be filovirus-positive on the basis of intrinsic trait similarity with known filovirus-positive bats. New bat species predicted to be positive for filoviruses are widely distributed outside of equatorial Africa, with a majority of species overlapping in Southeast Asia. Taken together, these results spotlight several potential host species and geographical regions as high-probability targets for future filovirus surveillance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.