ArticlePLoS pathogens2016
Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed.
- A hybrid transcriptome assembly reveals coding and noncoding landscapes in Drosophila hemocytes.Genetics · 2026Article
- Horizontal gene transfer rivals gene duplication as a source of anti-parasitoid immune innovation in the Drosophilidae.bioRxiv : the preprint server for biology · 2026Article
- COP9 signalosome regulates EGFR and Notch signaling during myeloid-type progenitor cell fate decision in Drosophila.EMBO reports · 2026Article
- Cdc42 and Rac2 act through the formin-like Frl/FMNL to control lamellocyte shape and encapsulation of parasitoid wasp eggs in Drosophila.PLoS pathogens · 2026Article
- Bendless-mediated K63 ubiquitination modulates cellular signalling to regulate Drosophila hematopoiesis.Cell communication and signaling : CCS · 2026Article
- Drosophila Abi maintains blood cell homeostasis by promoting clathrin-mediated endocytosis of Notch.The Journal of cell biology · 2026Article
- mTOR signaling regulates demand-adapted hematopoiesis and metabolic reprogramming required for an effective cellular immune response in Drosophila melanogaster larvae.PLoS genetics · 2026Article
- IbinA and IbinB regulate the Toll pathway-mediated immune response in Drosophila melanogaster.BMC biology · 2026Article
- Nociceptor activity is required for a robust immune response inmicroPublication biology · 2026Article
- A single-cell transcriptomic dataset of enterocyte-specific HHEX knockdown in the Drosophila larval midgut.Scientific data · 2025Article
- ROS produced by Dual oxidase regulate cell proliferation and haemocyte migration during leg regeneration in the cricket.Development (Cambridge, England) · 2025Article
- Methotrexate alleviates chronic inflammation in a Drosophila model.Journal of cell science · 2025Article
- Multifaceted Defenses Against Parasitoid Wasps in Diptera.Annual review of genetics · 2025Review
- ThebioRxiv : the preprint server for biology · 2025Article
- A rare, evolutionarily conserved venom protein benefits endoparasitism across parasitoids.Cell genomics · 2025Article
- Genetic perturbation of cellular homeostasis regulates integrated stress response signaling to control Drosophila hematopoiesis.Biology open · 2025Article
- Multigenerational inheritance of parasitic stress memory inEnvironmental epigenetics · 2025Article
- Pore-Forming Toxin-Like Proteins in the Anti-Parasitoid Immune Response of Drosophila.Journal of innate immunity · 2025Article
- A novel role for Hsc70-4 in blood cell differentiation inFrontiers in immunology · 2025Article
- Characterising phagocytes and measuring phagocytosis from live Galleria mellonella larvae.Virulence · 2024Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cellular immune responses require the generation and recruitment of diverse blood cell types that recognize and kill pathogens. In Drosophila melanogaster larvae, immune-inducible lamellocytes participate in recognizing and killing parasitoid wasp eggs. However, the sequence of events required for lamellocyte generation remains controversial. To study the cellular immune system, we developed a flow cytometry approach using in vivo reporters for lamellocytes as well as for plasmatocytes, the main hemocyte type in healthy larvae. We found that two different blood cell lineages, the plasmatocyte and lamellocyte lineages, contribute to the generation of lamellocytes in a demand-adapted hematopoietic process. Plasmatocytes transdifferentiate into lamellocyte-like cells in situ directly on the wasp egg. In parallel, a novel population of infection-induced cells, which we named lamelloblasts, appears in the circulation. Lamelloblasts proliferate vigorously and develop into the major class of circulating lamellocytes. Our data indicate that lamellocyte differentiation upon wasp parasitism is a plastic and dynamic process. Flow cytometry with in vivo hemocyte reporters can be used to study this phenomenon in detail.
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