ArticleThe International journal of eating disorders2016
Mammillary body volume abnormalities in anorexia nervosa.
Article in The International journal of eating disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Novel Mammillary Body Manual Segmentation: Application for Quantitative MRI Analysis of Critically Ill Infants.Clinical neuroimaging (Hoboken, N.J.) · 2025Article
- Do the mammillary bodies atrophy with aging? A magnetic resonance imaging study.Surgical and radiologic anatomy : SRA · 2023Article
- The Mammillary Bodies: A Review of Causes of Injury in Infants and Children.AJNR. American journal of neuroradiology · 2022Review
- Reduced brain mammillary body volumes and memory deficits in adolescents who have undergone the Fontan procedure.Pediatric research · 2020Article
- Atrophy of the ipsilateral mammillary body in unilateral hippocampal sclerosis shown by thin-slice-reconstructed volumetric analysis.Neuroradiology · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveSeveral case reports of Wernicke's Encephalopathy in anorexia nervosa (AN) caused by thiamine deficiency have described mammillary body (MB) injury, but systematic studies are lacking. Here we evaluated whether underweight and weight-restored individuals with AN demonstrate evidence of abnormal MB morphology, via retrospective examination of a previously collected data set.
methodUsing standard-resolution T1-weighted magnetic resonance imaging at 3 Tesla, we measured MB volume and fornix area in a cross-sectional study of 12 underweight AN, 20 weight-restored AN, and 30 age- and sex-matched healthy comparisons. Because of the small size of these structures, a manual tracing approach was necessary to obtain accurate measurements. A blinded expert rater manually traced MB and fornix structures in each participant.
resultsWe observed significantly smaller MB volumes in the underweight AN group. However, the weight-restored AN group exhibited significantly larger MB volumes. The right fornix was smaller in the weight-restored AN group only. DISCUSSION: These findings suggest the possibility that MB volume and fornix area could represent potential biomarkers of acute weight loss and restoration, respectively. Verification of this finding through prospective studies evaluating MB morphology, cognition, and thiamine levels longitudinally across individual illness trajectories might be warranted. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:920-929).
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