The Effect of Glutamate Receptor Agonists on Mouse Retinal Astrocyte [Ca(2+)]i.

Stephanie N Blandford, William H Baldridge

Open access · hybridAbstract read

In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 96% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Stephanie N BlandfordRetina and Optic Nerve Research Laboratory, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2; Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2.

William H BaldridgeRetina and Optic Nerve Research Laboratory, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2; Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2; Department of Ophthalmology & Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2.ORCID 0000-0002-1847-8147

Dalhousie University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium-imaging techniques were used to determine if mouse retinal astrocytes in situ respond to agonists of ionotropic (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, AMPA; N-methyl-D-aspartate, NMDA) and metabotropic (S-3,5-dihydroxyphenylglycine, DHPG; trans-1-amino-1,3-cyclopentanedicarboxylic acid, ACPD) glutamate receptors. In most cases we found no evidence that retinal astrocyte intracellular calcium ion concentration ([Ca(2+)]i) increased in response to these glutamate agonists. The one exception was AMPA that increased [Ca(2+)]i in some, but not all, mouse retinal astrocytes in situ. However, AMPA did not increase [Ca(2+)]i in mouse retinal astrocytes in vitro, suggesting that the effect of AMPA in situ may be indirect.

Indexed as

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAstrocytesCalciumCycloleucineExcitatory Amino Acid AgonistsFura-2MethoxyhydroxyphenylglycolMice, Inbred C57BLN-MethylaspartateReceptors, GlutamateRetina1-amino-1,3-dicarboxycyclopentane3,4-dihydroxyphenylglycolalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCalciumCycloleucineExcitatory Amino Acid AgonistsFura-2MethoxyhydroxyphenylglycolN-MethylaspartateReceptors, Glutamate

Identifiers

PMID27413752

DOI10.1155/2016/8178162

PMCPMC4930813

OpenAlexW2438936284

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.