Evidence map›Paper›PMID 27413711›Full record

ReviewTranslational lung cancer research2016

Non-small cell lung cancer: current treatment and future advances.

Cecilia Zappa, Shaker A Mousa

4 registry-linked trialsAbstract readReview
In one paragraph

Review in Translational lung cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 1,066 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,066citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03883243 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Monitoring and Telecoaching of Physical Activity in Patients With Stage III and IV Non-small Cell Lung Cancer

TypeinterventionalSponsorKU LeuvenRan2019 to 2020Enrolled32ConditionsExercise, NeoplasmsArmsTelecoaching
NCT06048315 phase3not yet recruitingnot on this mapstarted 2023, after this paper: background citation

A Single Center, Single Arm Clinical Study on the Treatment of Advanced Non-small Cell

TypeinterventionalSponsorDegan LuRan2023 to 2026Enrolled52ConditionsLung Cancer, TKI Resistance, EGFR Sensitive Mutation, AnlotinibArmsAnlotinib, Penpulimab
NCT07014202 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Comparing Consolidation Radiotherapy Versus No Radiotherapy for Oligoresidual Disease After First-line Chemotherapy Plus Immunotherapy in Advanced Non-Small Cell Lung Cancer: A Prospective, Randomized Controlled Phase II Clinical Trial

TypeinterventionalSponsorCancer Institute and Hospital, Chinese Academy of Medical SciencesRan2025 to 2027Enrolled224ConditionsNon-Small Cell Lung CancerArmsImmunotherapy (with or without chemotherapy) maintenance therapy combined with radiotherapy, Immunotherapy (with or without chemotherapy) maintenance therapy
NCT07744698 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of Metronomic Oral Paclitaxel Plus an Immune Checkpoint Inhibitor as Maintenance Therapy After First-Line Induction in Advanced Squamous Non-Small Cell Lung Cancer and Extensive-Stage Small Cell Lung Cancer: A Multicenter, Multi-Cohort Exploratory Study

TypeinterventionalSponsorAnhui Provincial Cancer HospitalRan2026 to 2029Enrolled107ConditionsSquamous Non-Small Cell Lung Cancer sqNSCLC, Extensive-stage Small Cell Lung Cancer (ES-SCLC)ArmsPaclitaxel Oral Solution, PD-1/PD-L1 inhibitor (eg. Tislelizumab)
3 · Its place in the literature

Who cites it

1,066 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  14. NRF2 signaling drives chemoresistance in NSCLC and glioblastoma.Molecular and cellular biochemistry · 2026
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1,006 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cecilia ZappaThe Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, New York, USA.
Shaker A MousaThe Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer has a poor prognosis; over half of people diagnosed with lung cancer die within one year of diagnosis and the 5-year survival is less than 18%. Non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases. Risk factors for developing NSCLC have been identified, with cigarette smoking being a major factor along with other environmental and genetic risk factors. Depending on the staging of lung cancer, patients are eligible for certain treatments ranging from surgery to radiation to chemotherapy as well as targeted therapy. With the advancement of genetics and biomarkers testing, specific mutations have been identified to better target treatment for individual patients. This review discusses current treatments including surgery, chemotherapy, radiotherapy, and immunotherapy as well as how biomarker testing has helped improve survival in patients with NSCLC.

Indexed as

Chemotherapyimmunotherapynon-small cell lung cancer (NSCLC)

Identifiers

PMID27413711
PMCPMC4931124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.