Evidence map›Paper›PMID 27413551›Full record

ReviewInternational journal of breast cancer2016

Breast Cancer in Africa: Limitations and Opportunities for Application of Genomic Medicine.

Allison Silverstein, Rachita Sood, Ainhoa Costas-Chavarri

Abstract readReview
In one paragraph

Review in International journal of breast cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Heliyon · 2023
    Article
  6. Article
  7. Breast cancer in sub-Saharan Africa: The current state and uncertain future.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Pathology of Senegalese breast cancers.The Pan African medical journal · 2019
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Allison SilversteinDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Program in Global Surgery and Social Change, Boston, MA 02115, USA; University of Miami Miller School of Medicine, Miami, FL 33136, USA; Rwanda Military Hospital, Kigali, Rwanda.ORCID 0000-0003-4188-8424
Rachita SoodDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Program in Global Surgery and Social Change, Boston, MA 02115, USA; University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Ainhoa Costas-ChavarriDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Program in Global Surgery and Social Change, Boston, MA 02115, USA; Rwanda Military Hospital, Kigali, Rwanda.ORCID 0000-0002-0943-2892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As genomic medicine gains clinical applicability across a spectrum of diseases, insufficient application in low-income settings stands to increase health disparity. Breast cancer screening, diagnosis, and treatment have benefited greatly from genomic medicine in high-income settings. As breast cancer is a leading cause of both cancer incidence and mortality in Africa, attention and resources must be applied to research and clinical initiatives to integrate genomic medicine into breast cancer care. In terms of research, there is a paucity of investigations into genetic determinants of breast cancer specific to African populations, despite consensus in the literature that predisposition and susceptibility genes vary between populations. Therefore, we need targeted strengthening of existing research efforts and support of new initiatives. Results will improve clinical care through screening and diagnosis with genetic testing specific to breast cancer in African populations. Clinically, genomic medicine can provide information capable of improving resource allocation to the population which most stands to benefit from increased screening or tailored treatment modalities. In situations where mammography or chemotherapy options are limited, this information will allow for the greatest impact. Implementation of genomic medicine will face numerous systemic barriers but is essential to improve breast cancer outcomes and survival.

Identifiers

PMID27413551
PMCPMC4927988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.