Evidence map›Paper›PMID 27413521›Full record

ArticleMediterranean journal of hematology and infectious diseases2016

Clinical and Laboratory Characteristics of Dengue-Orientia tsutsugamushi co-Infection from a Tertiary Care Center in South India.

Aneesh Basheer, Nayyar Iqbal, Sudhagar Mookkappan, Patricia Anitha, Shashikala Nair, Reba Kanungo, Ravichandran Kandasamy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediterranean journal of hematology and infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Scrub typhus: risks, diagnostic issues, and management challenges.Research and reports in tropical medicine · 2017
    Review
  10. Neurological Manifestations of Dengue Fever.Annals of Indian Academy of Neurology
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aneesh BasheerDepartment of General Medicine, Pondicherry Institute of Medical Sciences, Ganapathichettikulam, Kalapet, Pondicherry - 605014.
Nayyar IqbalDepartment of General Medicine, Pondicherry Institute of Medical Sciences, Ganapathichettikulam, Kalapet, Pondicherry - 605014.
Sudhagar MookkappanDepartment of General Medicine, Pondicherry Institute of Medical Sciences, Ganapathichettikulam, Kalapet, Pondicherry - 605014.
Patricia AnithaDepartment of Microbiology, Pondicherry Institute of Medical Sciences, Ganapathichettikulam, Kalapet, Pondicherry - 605014.
Shashikala NairDepartment of Microbiology, Pondicherry Institute of Medical Sciences, Ganapathichettikulam, Kalapet, Pondicherry - 605014.
Reba KanungoDepartment of Microbiology, Pondicherry Institute of Medical Sciences, Ganapathichettikulam, Kalapet, Pondicherry - 605014.
Ravichandran KandasamyDepartment of Biostatistics, Pondicherry Institute of Medical Sciences, Ganapathichettikulam, Kalapet, Pondicherry - 605014.
Pondicherry Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConcurrent infection with multiple pathogens is common in tropics, posing diagnostic and treatment challenges. Although co-infections of dengue, malaria, leptospirosis and typhoid in various combinations have been described, data on dengue and scrub typhus co-infection is distinctly limited. METHODOLOGY: This study was a retrospective analysis of dengue and scrub typhus co-infection diagnosed between January 2010 and July 2014 at a tertiary care center. Clinical and laboratory features of these cases were compared with age and gender-matched patients with isolated dengue fever and isolated scrub typhus. Positive test for dengue non-structural 1 (NS1) antigen was considered diagnostic of dengue whereas scrub typhus was diagnosed by IgM scrub antibodies demonstrated by ELISA.

resultsThere were 6 cases of dengue-scrub co-infection during the review period which fitted clinical and laboratory profile with a mean age of 42.5 years. Fever, headache, and arthralgia were common. Normal hemoglobin, significant thrombocytopenia, transaminitis, and hypoalbuminemia were identified in these patients. Compared to patients with isolated dengue, those with co-infection had higher pulse rate, lower systolic blood pressure, normal leucocyte counts, higher levels of liver enzymes, greater prolongation of partial thromboplastin time (aPTT) and lower serum albumin. Co-infection was characterized by a lower nadir platelet count compared to scrub typhus, and lesser time to nadir platelet count and longer duration of hospital stay compared to either isolated dengue or scrub typhus.

conclusionDengue-scrub typhus co-infection may be under-diagnosed in tropics, particularly confounded during dengue epidemics. Normal leukocyte counts, early drop in platelets and hypoalbuminemia in dengue patients could be clues to concurrent scrub typhus infection. Prompt recognition and treatment of scrub typhus in such cases may reduce unnecessary hospital stay and cost.

Identifiers

PMID27413521
PMCPMC4928539
OpenAlexW2423211451

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.