ArticleJournal of parasitic diseases : official organ of the Indian Society for Parasitology2016
Evaluation of the antileishmanial and cytotoxic effects of various extracts of garlic (Allium sativum) on Leishmania tropica.
Article in Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The Safety and Efficacy of an Immunomodulator Garlic-Based Cream (LeishG1) for Treating Uncomplicated Cutaneous Leishmaniasis: A Single-Blind, Multi-Center Study.Health science reports · 2025Article
- Potential activity ofFrontiers in pharmacology · 2025Article
- Antileishmanial and synergic effects of Rhanterium epapposum essential oil and its main compounds alone and combined with glucantime against Leishmania major infection.International journal for parasitology. Drugs and drug resistance · 2024Article
- Antinociceptive and anti-inflammatory activities of the methanol extract ofArchives of Razi Institute · 2024Article
- The influence of plant extracts on viability of ST3 and ST7 subtypes of Blastocystis sp.Gut pathogens · 2024Article
- In vitro anti-Archives of Razi Institute · 2024Article
- Newly fabricated zinc oxide nanoparticles loaded materials for therapeutic nano delivery in experimental cryptosporidiosis.Scientific reports · 2023Article
- Immunomodulatory, Antioxidant, and Anti-Inflammatory Activities of Green Synthesized Copper Nanoparticles for Treatment of ChronicPharmaceuticals (Basel, Switzerland) · 2023Article
- Synthesis, characterization and evaluation of prenylated chalcones ethers as promising antileishmanial compounds.Molecular diversity · 2023Article
- In vitro and in vivo antileishmanial effects ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Anti-Tropical medicine and infectious disease · 2023Article
- In vitro and in vivo Anti-Infection and drug resistance · 2021Article
- Medicinal plants with promising antileishmanial activity in Iran: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2017Review
- Antileishmanial and Immunomodulatory Activity of Allium sativum (Garlic): A Review.Journal of evidence-based complementary & alternative medicine · 2017Review
- The Potential Use of Methotrexate in the Treatment of Cutaneous Leishmaniasis: In Vitro Assays against Sensitive and Meglumine Antimoniate-resistant Strains ofIranian journal of parasitologyArticle
- Green Synthesis, Characterization, and Antileishmanial Activity of the Silver Nanoparticles Alone and Along with Meglumine Antimoniate againstIranian journal of parasitologyArticle
- In Vitro Study of Leishmanicidal Activity of Biogenic Selenium Nanoparticles against Iranian Isolate of Sensitive and Glucantime-Resistant Leishmania tropica.Iranian journal of parasitologyArticle
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cutaneous leishmaniasis (CL) is a major public health problem in tropical and subtropical countries worldwide. Treatment of CL by pentavalent antimony compounds remains a challenge because of limited efficacy, toxic side effects and drug resistance. In the present study, in vitro antileishmanial and cytotoxic activity of garlic extracts against promastigote forms of Leishmania tropica and murine macrophages was evaluated by colorimetric cell viability (MTT) assay. The results revealed that the methanolic and aqueous extracts of garlic were effective in inhibiting promastigote growth of L. tropica with IC50 (50 % inhibitory concentrations) values 12.3 and 19.2 µg/ml, respectively. In addition, methanolic and aqueous extracts of garlic showed low cytotoxicity against murine macrophages with CC50 (cytotoxicity concentration for 50 % of cells) values 291.4 and 348.2 µg/ml, respectively. Findings of present study were the first step in the search for new antileishmanial drugs. However, further works are required to evaluate exact effect of these extracts in volunteer human subjects.
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