Evidence map›Paper›PMID 27413197›Full record

ArticleAmerican journal of physiology. Renal physiology2016

Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone.

YiLin Ren, Branislava Janic, Kristopher Kutskill, Edward L Peterson, Oscar A Carretero

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Effects of reactive oxygen species on renal tubular transport.American journal of physiology. Renal physiology · 2019
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

YiLin RenHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan; and.
Branislava JanicHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan; and.
Kristopher KutskillHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan; and.
Edward L PetersonDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.
Oscar A CarreteroHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan; and ocarret1@hfhs.org.
Henry Ford Hospital · US

Funding

VASOACTIVE HORMONES IN THE REGULATION OF BLOOD PRESSUREP01HL028982 · NHLBI · HENRY FORD HOSPITAL · PI GARVIN, JEFFREY L. · 1985 to 2017
$39.8M
NHLBI NIH HHS P01 HL028982
6 · The paper itself

Abstract

Connecting tubule glomerular feedback (CTGF) is a mechanism where an increase in sodium (Na) concentration in the connecting tubule (CNT) causes the afferent arteriole (Af-Art) to dilate. We recently reported that aldosterone within the CNT lumen enhances CTGF via a nongenomic effect involving GPR30 receptors and sodium/hydrogen exchanger (NHE), but the signaling pathways of this mechanism are unknown. We hypothesize that aldosterone enhances CTGF via cAMP/protein kinase A (PKA) pathway that activates protein kinase C (PKC) and stimulates superoxide (O

Indexed as

AldosteroneAnimalsCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic N-OxidesDose-Response Relationship, DrugFeedback, PhysiologicalIsoquinolinesKidney GlomerulusMaleProtein Kinase CRabbitsSignal TransductionSodium ChlorideSpin LabelsSulfonamidesAldosteroneCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic N-OxidesIsoquinolinesN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideProtein Kinase CSodium ChlorideSpin LabelsSulfonamidestempolarteriolesdistal kidney tubulesPKA inhibitorsuperoxide

Identifiers

PMID27413197
PMCPMC5210193
OpenAlexW2469535479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.