ArticleThe American journal of clinical nutrition2016
Dietary flavonoid intake and risk of incident depression in midlife and older women.
Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.
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Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Association between Fruit and Vegetable Consumption and Depression Symptoms in Young People and Adults Aged 15-45: A Systematic Review of Cohort Studies.International journal of environmental research and public health · 2021Pooled it
- Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression: A Systematic Literature Review.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Evidence of the Importance of Dietary Habits Regarding Depressive Symptoms and Depression.International journal of environmental research and public health · 2020Pooled it
- The Effects of Dietary Improvement on Symptoms of Depression and Anxiety: A Meta-Analysis of Randomized Controlled Trials.Psychosomatic medicine · 2019Pooled it
- A biphasic response to blueberry supplementation on depressive symptoms in emerging adults: a double-blind randomized controlled trial.European journal of nutrition · 2024Trial
- Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial.Nutrients · 2022Trial
- Mental Health in New Mothers: A Randomised Controlled Study into the Effects of Dietary Flavonoids on Mood and Perceived Quality of Life.Nutrients · 2021Trial
- Flavonoid-Rich Orange Juice Intake and Altered Gut Microbiome in Young Adults with Depressive Symptom: A Randomized Controlled Study.Nutrients · 2020Trial
- Trial
- Flavonoid intake and telomere length attrition among middle-aged women: a cross-sectional analysis of the Nurses' Health Study.GeroScience · 2026Article
- Regular intake of caffeinated but not decaffeinated coffee attenuates behavioral modifications in mice subject to chronic unpredictable stress.Neurobiology of stress · 2026Article
- Evaluation of the relationship between sustainable and healthy eating behaviours, phytochemical index, anthropometric measurements, and depression in young adults.Scientific reports · 2026Article
- Validation and reproducibility of a novel flavonoid food frequency dietary assessment tool (Flav-Q) against multiple 24-h recalls across 12 months.European journal of nutrition · 2026Article
- Dietary flavonoid intake and psychological well-being - A bidirectional relationship.Clinical nutrition (Edinburgh, Scotland) · 2026Article
- Incidence rates of twelve chronic diseases/conditions in US adults: findings from a population-based study.Lancet regional health. Americas · 2026Article
- Research progress on plant-derived bioactive compounds and late-life depression: from neuroprotective mechanisms to dietary patterns.Frontiers in nutrition · 2026Review
- Plant-derived bioactives in depression-related and antidepressant-associated sexual dysfunction: a narrative review.Frontiers in nutrition · 2026Review
- Polyphenol intake and depressive symptoms in young adults: evidence from a population-based longitudinal study.The British journal of nutrition · 2025Article
- Dietary Phytochemicals and Depressive Symptoms in Young Adults: Evidence from Undergraduate Students in Türkiye.Nutrients · 2025Article
- Evaluation of the Relationship Between Job Stress Level, Adherence to the Mediterranean Diet, and Phytochemical Index.Nutrients · 2025Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe impact of dietary flavonoid intakes on risk of depression is unclear.
objectiveWe prospectively examined associations between estimated habitual intakes of dietary flavonoids and depression risk.
designWe followed 82,643 women without a previous history of depression at baseline from the Nurses' Health Study [(NHS) aged 53-80 y] and the Nurses' Health Study II [(NHSII) aged 36-55 y]. Intakes of total flavonoids and subclasses (flavonols, flavones, flavanones, anthocyanins, flavan-3-ols, polymeric flavonoids, and proanthocyanidins) were calculated from validated food-frequency questionnaires collected every 2-4 y. Depression was defined as physician- or clinician-diagnosed depression or antidepressant use and was self-reported in response to periodic questionnaires. Cox proportional hazards models were performed to examine associations.
resultsA total of 10,752 incident depression cases occurred during a 10-y follow-up. Inverse associations between flavonol, flavone, and flavanone intakes and depression risk were observed. Pooled multivariable-adjusted HRs (95% CIs) were 0.93 (0.88, 0.99), 0.92 (0.86, 0.98), and 0.90 (0.85, 0.96) when comparing the highest (quintile 5) with the lowest (quintile 1) quintiles, respectively, with evidence of linear trends across quintiles (P-trend = 0.0004-0.08). In flavonoid-rich food-based analyses, the HR was 0.82 (95% CI: 0.74, 0.91) among participants who consumed ≥2 servings citrus fruit or juices/d compared with <1 serving/wk. In the NHS only, total flavonoids, polymers, and proanthocyanidin intakes showed significantly (9-12%) lower depression risks. In analyses among late-life NHS participants (aged ≥65 y at baseline or during follow-up), for whom we were able to incorporate depressive symptoms into the outcome definition, higher intakes of all flavonoid subclasses except for flavan-3-ols were associated with significantly lower depression risk; flavones and proanthocyanidins showed the strongest associations (HR for both: 0.83; 95% CI: 0.77, 0.90).
conclusionsHigher flavonoid intakes may be associated with lower depression risk, particularly among older women. Further studies are needed to confirm these associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.