ArticleInternational journal of epidemiology2016
Birthweight, childhood growth and left ventricular structure at age 60-64 years in a British birth cohort study.
Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Childhood Risk Factors and Adulthood Cardiovascular Disease: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- The Association of Maternal Pre-Pregnancy Overweight with Childhood BMI Trajectories and Blood Pressure.Healthcare (Basel, Switzerland) · 2026Article
- Foetal Metformin Exposure, Childhood Adiposity and Future Cardiovascular Risk: Can We Connect the Dots?TouchREVIEWS in endocrinology · 2025Review
- Adulthood adiposity affects cardiac structure and function in later life.European heart journal · 2024Article
- Sex-Specific Differences in Left Ventricular Mass and Volumes with Body Mass Index among Children Aged 6 to 8: A Cross-Sectional Study in China.Nutrients · 2023Article
- The association of gestational age and birthweight with blood pressure, cardiac structure, and function in 4 years old: a prospective birth cohort study.BMC medicine · 2023Article
- Association between carotid atherosclerosis and brain activation patterns during the Stroop task in older adults: An fNIRS investigation.NeuroImage · 2022Article
- Parents' awareness and perceptions of the Change4Life 100 cal snack campaign, and perceived impact on snack consumption by children under 11 years.BMC public health · 2022Article
- Study protocol: MyoFit46-the cardiac sub-study of the MRC National Survey of Health and Development.BMC cardiovascular disorders · 2022Article
- Childhood growth and development and DNA methylation age in mid-life.Clinical epigenetics · 2021Article
- Investigating the relationship between BMI across adulthood and late life brain pathologies.Alzheimer's research & therapy · 2021Article
- Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study.Osteoarthritis and cartilage · 2021Article
- Study Protocol - Insight 46 Cardiovascular: A Sub-study of the MRC National Survey of Health and Development.Artery research · 2020Article
- Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort.JAMA neurology · 2020Article
- Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study.The Lancet. Neurology · 2019Article
- Effective implementation of primary school-based healthy lifestyle programmes: a qualitative study of views of school staff.BMC public health · 2019Article
- Birth weight and cardiac function assessed by echocardiography in adolescence: Avon Longitudinal Study of Parents and Children.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2019Article
- The relationship between pubertal timing and markers of vascular and cardiac structure and function in men and women aged 60-64 years.Scientific reports · 2019Article
- Adjustment for time-invariant and time-varying confounders in 'unexplained residuals' models for longitudinal data within a causal framework and associated challenges.Statistical methods in medical research · 2019Article
- The feasibility and acceptability of a primary school-based programme targeting diet and physical activity: the PhunkyFoods Programme.Pilot and feasibility studies · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHigh left ventricular mass (LVM) is an independent predictor of cardiovascular disease and mortality, but information relating LVM in older age to growth in early life is limited. We assessed the relationship of birthweight, height and body mass index (BMI) and overweight across childhood and adolescence with later life left ventricular (LV) structure.
methodsWe used data from the MRC National Survey of Health and Development (NSHD) on men and women born in 1946 in Britain and followed up ever since. We use regression models to relate prospective measures of birthweight and height and BMI from ages 2-20 years to LV structure at 60-64 years.
resultsPositive associations of birthweight with LVM and LV end diastolic volume (LVEDV) at 60-64 years were largely explained by adult height. Higher BMI, greater changes in BMI and greater accumulation of overweight across childhood and adolescence were associated with higher LVM and LVEDV and odds of concentric hypertrophy. Those who were overweight at two ages in early life had a mean LVM 11.5 g (95% confidence interval: -2.19,24.87) greater, and a mean LVEDV 10.0 ml (3.7,16.2) greater, than those who were not overweight. Associations were at least partially mediated through adult body mass index. Body size was less consistently associated with relative wall thickness (RWT), with the strongest association being observed with pubertal BMI change [0.007 (0.001,0.013) per standard deviation change in BMI 7-15 years]. The relationships between taller childhood height and LVM and LVEDV were explained by adult height.
conclusionsGiven the increasing levels of overweight in contemporary cohorts of children, these findings further emphasize the need for effective interventions to prevent childhood overweight.
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