SynthesisInternational journal of epidemiology2016
Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes.
Synthesis in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- Causal Relationship Between Branched-Chain Amino Acids and Hypertension: A Mendelian Randomization Study.Journal of the American Heart Association · 2024Pooled it
- Trial
- Trial
- Association of Modifiable Lifestyle Factors with Plasma Branched-Chain Amino Acid Metabolites in Women.The Journal of nutrition · 2022Trial
- A Novel Dietary Intervention Reduces Circulatory Branched-Chain Amino Acids by 50%: A Pilot Study of Relevance for Obesity and Diabetes.Nutrients · 2020Trial
- Changes of Branched-Chain Amino Acids and Ectopic Fat in Response to Weight-loss Diets: the POUNDS Lost Trial.The Journal of clinical endocrinology and metabolism · 2020Trial
- Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study.The American journal of clinical nutrition · 2019Trial
- Trial
- Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial.Diabetologia · 2018Trial
- Dietary amino acid patterns and epilepsy among the PERSIAN cohort population: A cross-sectional study.Experimental physiology · 2026Article
- The emerging role of branched-chain amino acid metabolism in obesity.International journal of obesity (2005) · 2026Review
- Article
- Circulating Branched-Chain Amino Acids are Associated with Higher Odds of Obesity: Findings from the FiLWHEL Study.Nutrition and metabolic insights · 2026Article
- Distinct urine and plasma metabolic signatures in diabetic foot: early diagnostic biomarkers and predictive modeling.BMC endocrine disorders · 2025Article
- Metabolic Vulnerability Index and Atherosclerosis Incident: A Prospective Cohort Study From the UK Biobank.Journal of the American Heart Association · 2025Article
- The Gut Microbiota-Metabolic Axis: Emerging Insights from Human and Experimental Studies on Type 2 Diabetes Mellitus-A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Branched-Chain Amino Acid Intake and Risk of Incident Type 2 Diabetes: Results from the SUN Cohort.Biomedicines · 2025Article
- Noninvasive On-Skin Biosensors for Monitoring Diabetes Mellitus.Nano-micro letters · 2025Review
- Amino acid intake, plasma metabolites, and incident type 2 diabetes risk: a systematic approach in prospective cohort studies.Nutrition journal · 2025Observational
- Metabolomic Alterations in Patients with Obesity and the Impact of Metabolic Bariatric Surgery: Insights for Future Research.Metabolites · 2025Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPlasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D.
methodsWe assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010).
resultsWe documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01).
conclusionsOur data suggest that high consumption of BCAAs is associated with an increased risk of T2D.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.