Evidence map›Paper›PMID 27413068›Full record

ReviewClinical and vaccine immunology : CVI2016

Animal Models for Salmonellosis: Applications in Vaccine Research.

Ellen E Higginson, Raphael Simon, Sharon M Tennant

Open access · diamondAbstract readReview
In one paragraph

Review in Clinical and vaccine immunology : CVI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 54 citations in OpenAlex.

  1. Gut microbes · 2026
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  7. Quantification ofeLife · 2025
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  9. Quantification ofbioRxiv : the preprint server for biology · 2024
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  10. Review
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  13. TheVaccines · 2024
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  15. Microorganisms · 2023
    Review
  16. The Challenge Non-TyphoidalWellcome open research · 2023
    Article
  17. Article
  18. A Novel Approach againstVaccines · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ellen E HigginsonCenter for Vaccine Development and Institute for Global Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Raphael SimonCenter for Vaccine Development and Institute for Global Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sharon M TennantCenter for Vaccine Development and Institute for Global Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA stennant@medicine.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
NIAID NIH HHS U19 AI109776
6 · The paper itself

Abstract

Salmonellosis remains an important cause of human disease worldwide. While there are several licensed vaccines for Salmonella enterica serovar Typhi, these vaccines are generally ineffective against other Salmonella serovars. Vaccines that target paratyphoid and nontyphoidal Salmonella serovars are very much in need. Preclinical evaluation of candidate vaccines is highly dependent on the availability of appropriate scientific tools, particularly animal models. Many different animal models exist for various Salmonella serovars, from whole-animal models to smaller models, such as those recently established in insects. Here, we discuss various mouse, rat, rabbit, calf, primate, and insect models for Salmonella infection, all of which have their place in research. However, choosing the right model is imperative in selecting the best vaccine candidates for further clinical testing. In this minireview, we summarize the various animal models that are used to assess salmonellosis, highlight some of the advantages and disadvantages of each, and discuss their value in vaccine development.

Indexed as

Disease Models, AnimalAnimalsDrug Evaluation, PreclinicalInsectaMammalsPrimatesSalmonella InfectionsSalmonella VaccinesSalmonella Vaccines

Identifiers

PMID27413068
PMCPMC5014920
OpenAlexW2469755942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.