ArticleJournal of the American Heart Association2016
Obesity Is Associated With Progression of Atherosclerosis During Statin Treatment.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01212900. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The RIGHT Study: Risk Stratification With Image Guidance of HMG Coa Reductase Inhibitor Therapy
Open the trial in the graphWho cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Meta-analysis of the Relation of Body Mass Index to Cardiovascular Outcomes in Patients Receiving Intensive Low-Density Lipoprotein Cholesterol Lowering Therapy.The American journal of cardiology · 2020Pooled it
- MRI ensemble model of plaque and perivascular adipose tissue as PET-equivalent for identifying carotid atherosclerotic inflammation.EJNMMI research · 2025Article
- Predictors of Significant High-Sensitivity C-Reactive Protein Reduction After Use of Rosuvastatin/Amlodipine and Atorvastatin/Amlodipine-Subgroup Analysis in Randomized Controlled Trials.Journal of clinical medicine · 2025Article
- Article
- Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPARα/HO-1-Mediated Attenuation of Inflammation.Inflammation · 2024Article
- Identification of subgroups within a Japanese older adult population for whom statin therapy is effective in reducing mortality.PloS one · 2023Article
- Cardiovascular Risk in Patients with Chronic Kidney Disease with Special Reference to Statin Therapy.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Article
- Is Obesity a Risk Factor for Carotid Atherosclerotic Disease?-Opportunistic Review.Journal of cardiovascular development and disease · 2022Review
- Association of Hepatic Steatosis Index and Fatty Liver Index with Carotid Atherosclerosis in Type 2 Diabetes.International journal of medical sciences · 2021Observational
- Rationale, Design, and Implementation of Intensive Risk Factor Treatment in the CREST2 Trial.Stroke · 2020Article
- The Role of αInternational journal of molecular sciences · 2020Review
- Coronary CT Angiography and Carotid MRI Improve Phenotyping of Disease Extent Compared with ACC/AHA Risk Score Alone.Radiology. Cardiothoracic imaging · 2020Article
- The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease.Nutrients · 2019Review
- Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia.Seminars in arthritis and rheumatism · 2019Article
- DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass.Scientific reports · 2019Article
- LDL-C:HDL-C ratio and common carotid plaque in Xinjiang Uygur obese adults: a cross-sectional study.BMJ open · 2018Article
- Visceral Adipose Tissue Accumulation and Residual Cardiovascular Risk.Current hypertension reports · 2018Review
- Observational
- Tumor necrosis factor‑α and interleukin‑6 suppress microRNA‑1275 transcription in human adipocytes through nuclear factor‑κB.Molecular medicine reports · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study aimed to determine the relationship of statin therapy and cardiovascular risk factors to changes in atherosclerosis in the carotid artery. METHODS AND
resultsCarotid magnetic resonance imaging was used to evaluate 106 hyperlipidemic participants at baseline and after 12 months of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) treatment. Multivariable logistic regression was used to determine factors associated with progression (change in carotid wall volume >0) or regression (change ≤0) of carotid atherosclerosis. Computed tomography coronary calcium scores were obtained at baseline for all participants. The median age was 65 years (interquartile range 60-69 years), and 63% of the participants were male. Body mass index >30, elevated C-reactive protein, and hypertension were associated with increased carotid wall volume (obesity: odds ratio for progression 4.6, 95% CI 1.8-12.4, P<0.01; C-reactive protein: odds ratio for progression 2.56, 95% CI 1.17-5.73, P=0.02; hypertension: odds ratio 2.4, 95% CI 1.1-5.3, P<0.05). Higher statin dose was associated with regression of carotid wall volume (P<0.05). In multivariable analysis, obesity remained associated with progression (P<0.01), whereas statin use remained associated with regression (P<0.05). Change in atheroma volume in obese participants was +4.8% versus -4.2% in nonobese participants (P<0.05) despite greater low-density lipoprotein cholesterol reduction in obese participants.
conclusionsIn a population with hyperlipidemia, obese patients showed atheroma progression despite optimized statin therapy. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01212900.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.