ArticleDeutsches Arzteblatt international2016
Outpatient Antibiotic Prescription.
Article in Deutsches Arzteblatt international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Effectiveness of Pelargonium sidoides in pediatric patients diagnosed with uncomplicated upper respiratory tract infection: a single-blind, randomized, placebo-controlled study.European journal of pediatrics · 2021Trial
- Resistance reversal: Taiwan'sWorld journal of gastroenterology · 2025Article
- Similarities in the consumption trajectory of antibacterial drugs in the outpatient care sector in Germany from 1986 to 2022: identification of shared patterns, correlation analysis of prescribed defined daily dose and assessment of underlying influences.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Antibiotic self-medication in Otuke District, Northern Uganda: Prevalence and associated factors.PloS one · 2025Article
- Antibiotics Usage and Avoidance in Germany and Poland: Attitudes and Knowledge of Patients, Physicians, and Pharmacists.Antibiotics (Basel, Switzerland) · 2024Article
- Costs are a major driver of antibacterial drug prescriptions in Germany: market analysis from 1985 to 2022.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Patterns and trends of antibacterial treatment in patients with urinary tract infections, 2015-2019: an analysis of health insurance data.BMC primary care · 2022Article
- Lack of regulation over antibiotic prescription and dispensation: A prospective cohort in a community setting.Journal of infection prevention · 2021Article
- Antibiotic prescribing for acute, non-complicated infections in primary care in Germany: baseline assessment in the cluster randomized trial ARena.BMC infectious diseases · 2021Review
- Quality Appraisal of Ambulatory Oral Cephalosporin and Fluoroquinolone Use in the 16 German Federal States from 2014-2019.Antibiotics (Basel, Switzerland) · 2021Article
- Evaluation of a multimodal intervention to promote rational antibiotic use in primary care.Antimicrobial resistance and infection control · 2021Article
- The Decline in Outpatient Antibiotic Use.Deutsches Arzteblatt international · 2020Article
- Marked reductions in outpatient antibiotic prescriptions for children and adolescents - a population-based study covering 83% of the paediatric population, Germany, 2010 to 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
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- The rise in vancomycin-resistantAntimicrobial resistance and infection control · 2019Article
- Clinical pattern of antibiotic overuse and misuse in primary healthcare hospitals in the southwest of China.PloS one · 2019Article
- Comparing outpatient oral antibiotic use in Germany and the Netherlands from 2012 to 2016.Pharmacoepidemiology and drug safety · 2018Article
- Epidemiology of drug hypersensitivity reactions using 6-year national health insurance claim data from Korea.International journal of clinical pharmacy · 2018Article
- Antibiotic prescribing behavior among general practitioners - a questionnaire-based study in Germany.BMC infectious diseases · 2018Article
- Antibiotic use, knowledge and health literacy among the general population in Berlin, Germany and its surrounding rural areas.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn view of the rise in antibiotic resistance and Clostridium difficile superinfection, close monitoring of antibiotic prescribing practices is essential so that targeted quality assurance measures can be taken.
methodsWe analyzed nationwide data from multiple statutory health insurance carriers on prescriptions of systemic antibiotics in the years 2008-2014, with special attention to cephalosporins and fluoroqinolones. Prescribing rates were characterized in terms of defined daily doses (DDD) per 1000 statutory insurees per year and were analyzed separately for each age group and each federal state in Germany. Trends were analyzed with joinpoint regression.
resultsAntibiotic prescribing rates for persons aged 15 to 69 increased slightly overall during the period of observation. On the other hand, there was a significant decline in antibiotic prescribing rates for persons under age 15 in all of the German states, with a mean annual decrease of 6.8%. There was also a slight decline in antibiotic prescribing rates for persons aged 70 and above, mainly accounted for by fluoroquinolones. Cephalosporin prescribing rates rose significantly in all states, by an overall average of 7.6% per annum. Cephalo - sporin prescribing rates rose significantly in all age groups except persons under age 15, for whom there was a decline that did not reach statistical significance.
conclusionThis study revealed an overall decline in outpatient antibiotic prescriptions for persons under age 15 as well as other major changes in prescribing practices for the types of antibiotics studied. The observed marked rise in cephalosporin prescribing rates in all German states demands special attention because of the associated danger of increased antibiotic resistance and C. difficile superinfection. Oral cephalosporins are not recommended as drugs of first choice in current guidelines.
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