Evidence map›Paper›PMID 27412959›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders.

Monika Fleshner, Matthew Frank, Steven F Maier

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 223 citations in OpenAlex.

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  11. Therapeutic potential of COX-2 inhibitors in neuropsychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2025
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Monika FleshnerDepartment of Integrative Physiology, University of Colorado at Boulder, Boulder, CO, USA.
Matthew FrankCenter for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.ORCID 0000-0001-8613-6897
Steven F MaierCenter for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
University of Colorado Boulder · US

Funding

Stress-induced neuroinflammatory priming: Glucocorticoids, inflammasomes, alarminsR01MH108523 · NIMH · UNIVERSITY OF COLORADO · PI MAIER, STEVEN F · 2016 to 2020
$2.1M
NIMH NIH HHS R01 MH108523
6 · The paper itself

Abstract

Major depressive disorder (MDD) and other mood disorders remain difficult to effectively treat, and innovative interventions and therapeutic targets are needed. Psychological stressors and inappropriate inflammation increase the risk and severity of mood disorders; however, only recently have the importance of sterile inflammatory processes in this effect been revealed. This review will introduce the reader to pathogen vs sterile inflammation, inflammatory receptor-ligand interactions, microbial-associated molecular patterns (MAMPs), pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and the more recent discovery of the role of the inflammasome in peripheral and central nervous system cytokine/chemokine inflammatory responses. The review will focus on current preclinical and clinical evidence that sterile inflammation and inflammasome-dependent signaling may contribute to mood disorders. By understanding these inflammatory signaling processes, new approaches for quieting chronic or inappropriate inflammatory states may be revealed and this could serve as novel pharmacological targets for the treatment of mood disorders.

Indexed as

AnimalsCentral Nervous SystemHumansInflammasomesInflammationMicrogliaMood DisordersSignal TransductionStress, PsychologicalInflammasomes

Identifiers

PMID27412959
PMCPMC5143484
OpenAlexW2464749518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.