Evidence map›Paper›PMID 27412760›Full record

ArticleParasitology research2016

Early developmental stages of Ascaris lumbricoides featured by high-resolution mass spectrometry.

Carlos Fernando Odir Rodrigues Melo, Cibele Zanardi Esteves, Rosimeire Nunes de Oliveira, Tatiane Melina Guerreiro, Diogo Noin de Oliveira, Estela de Oliveira Lima, Júlio César Miné, Silmara Marques Allegretti, Rodrigo Ramos Catharino

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In one paragraph

Article in Parasitology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Serum Metabolic Alterations upon Zika Infection.Frontiers in microbiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Carlos Fernando Odir Rodrigues MeloInnovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Cibele Zanardi EstevesInnovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Rosimeire Nunes de OliveiraBiology Institute, Animal Biology Department, University of Campinas, Campinas, São Paulo, Brazil.
Tatiane Melina GuerreiroInnovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Diogo Noin de OliveiraInnovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Estela de Oliveira LimaInnovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Júlio César MinéDepartment of Clinical and Toxicological Analysis, State University of Ponta Grossa- UEPG, Ponta Grossa, Paraná, Brazil.
Silmara Marques AllegrettiBiology Institute, Animal Biology Department, University of Campinas, Campinas, São Paulo, Brazil. sallegre@unicamp.br.
Rodrigo Ramos CatharinoInnovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil. rrc@fcm.unicamp.br.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Estadual de Ponta Grossa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ascaris lumbricoides is responsible for a highly disseminated helminth parasitic disease, ascariosis, a relevant parasitosis that responds for great financial burden on the public health system of developing countries. In this work, metabolic fingerprinting using high-resolution mass spectrometry (HRMS) was employed to identify marker molecules from A. lumbricoides in different development stages. We have identified nine biomarkers, such as pheromones and steroidal prohormones in early stages, among other molecules in late development stages, making up four molecules for fertilized eggs, four marker molecules for first larvae (L1) and one marker molecule for third larvae (L3). Therefore, our findings indicate that this approach is suitable for biochemical characterization of A. lumbricoides development stages. Moreover, the straightforward analytical method employed, with almost no sample preparation from a complex matrix (feces) using high-resolution mass spectrometry, suggests that it is possible to seek for an easier and faster way to study animal molding processes.

Indexed as

MetabolomicsAnimalsAscariasisAscaris lumbricoidesBiomarkersFecesFemaleHumansLarvaMaleMass SpectrometryBiomarkersAscaris lumbricoidesMass spectrometryMetabolomics

Identifiers

PMID27412760
OpenAlexW2465277267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.