ArticleGenetics2016
Effector-Triggered Immune Response in Arabidopsis thaliana Is a Quantitative Trait.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- From gene-for-gene to NLRome-for-effectorome: decoding the dynamic interplay between phytopathogenic effector networks and plant immune systems.FEMS microbiology reviews · 2026Review
- Cyclic-di-GMP controls Type III effector export and symptom development in Pseudomonas syringae infections via the export ATPase HrcN.PLoS pathogens · 2025Article
- Integrated Assays of Genome-Wide Association Study, Multi-Omics Co-Localization, and Machine Learning Associated Calcium Signaling Genes with Oilseed Rape Resistance toInternational journal of molecular sciences · 2024Article
- Article
- Broader functions of TIR domains in Arabidopsis immunity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Study of natural diversity in response to a key pathogenicity regulator of Ralstonia solanacearum reveals new susceptibility genes in Arabidopsis thaliana.Molecular plant pathology · 2022Article
- A phytobacterial TIR domain effector manipulates NADThe New phytologist · 2022Article
- A genome-wide association study reveals cytokinin as a major component in the root defense responses against Ralstonia solanacearum.Journal of experimental botany · 2021Article
- Rapid identification of an Arabidopsis NLR gene as a candidate conferring susceptibility to Sclerotinia sclerotiorum using time-resolved automated phenotyping.The Plant journal : for cell and molecular biology · 2020Article
- The Polyamine Putrescine Contributes to HFrontiers in plant science · 2019Article
- Recent Advances in Mechanisms of Plant Defense toFrontiers in plant science · 2019Review
- Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene.PLoS genetics · 2018Article
- Defining essential processes in plant pathogenesis with Pseudomonas syringae pv. tomato DC3000 disarmed polymutants and a subset of key type III effectors.Molecular plant pathology · 2018Review
- Plastic Transcriptomes Stabilize Immunity to Pathogen Diversity: The Jasmonic Acid and Salicylic Acid Networks within the Arabidopsis/The Plant cell · 2017Article
- Diverse mechanisms of resistance to Pseudomonas syringae in a thousand natural accessions of Arabidopsis thaliana.The New phytologist · 2017Article
- Mechanisms to Mitigate the Trade-Off between Growth and Defense.The Plant cell · 2017Review
- Quantitative Resistance: More Than Just Perception of a Pathogen.The Plant cell · 2017Review
- TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genetic Interaction between ArabidopsisFrontiers in plant science · 2017Article
- Genome-Wide Association Studies In Plant Pathosystems: Toward an Ecological Genomics Approach.Frontiers in plant science · 2017Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
We identified loci responsible for natural variation in Arabidopsis thaliana (Arabidopsis) responses to a bacterial pathogen virulence factor, HopAM1. HopAM1 is a type III effector protein secreted by the virulent Pseudomonas syringae strain Pto DC3000. Delivery of HopAM1 from disarmed Pseudomonas strains leads to local cell death, meristem chlorosis, or both, with varying intensities in different Arabidopsis accessions. These phenotypes are not associated with differences in bacterial growth restriction. We treated the two phenotypes as quantitative traits to identify host loci controlling responses to HopAM1. Genome-wide association (GWA) of 64 Arabidopsis accessions identified independent variants highly correlated with response to each phenotype. Quantitative trait locus (QTL) mapping in a recombinant inbred population between Bur-0 and Col-0 accessions revealed genetic linkage to regions distinct from the top GWA hits. Two major QTL associated with HopAM1-induced cell death were also associated with HopAM1-induced chlorosis. HopAM1-induced changes in Arabidopsis gene expression showed that rapid HopAM1-dependent cell death in Bur-0 is correlated with effector-triggered immune responses. Studies of the effect of mutations in known plant immune system genes showed, surprisingly, that both cell death and chlorosis phenotypes are enhanced by loss of EDS1, a regulatory hub in the plant immune-signaling network. Our results reveal complex genetic architecture for response to this particular type III virulence effector, in contrast to the typical monogenic control of cell death and disease resistance triggered by most type III effectors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.