Evidence map›Paper›PMID 27412669›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2016

Nasal administration of leptin dose-dependently increases dopamine and serotonin outflow in the rat nucleus accumbens.

Sonya Neto, Ramya Varatharajan, Kevin Joseph, Andreas Moser

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sonya NetoDepartment of Neurology, Center of Brain, Behavior and Metabolism, Neurochemical Research Group, University of Lübeck, Lübeck, Germany. sonya.neto@neuro.uni-luebeck.de.ORCID 0000-0002-4675-2940
Ramya VaratharajanDepartment of Neurology, Center of Brain, Behavior and Metabolism, Neurochemical Research Group, University of Lübeck, Lübeck, Germany.
Kevin JosephDepartment of Neurology, Center of Brain, Behavior and Metabolism, Neurochemical Research Group, University of Lübeck, Lübeck, Germany.
Andreas MoserDepartment of Neurology, Center of Brain, Behavior and Metabolism, Neurochemical Research Group, University of Lübeck, Lübeck, Germany.
University of Freiburg · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptin is an anorexigenic hormone that acts via its receptor (LepR) to regulate the hypothalamic arcuate nucleus circuitry to mediate energy homeostasis and feeding behavior. Moreover, leptin decreases the reward value of natural and artificial rewards, and low levels of circulating leptin have been implicated in several mood disorders linking leptin to the mesolimbic system. Therefore, the purpose of this study was to assess whether and to what extent an acute intranasal application of leptin is able to modulate monoamine neurotransmitters in the nucleus accumbens (NAc). Microdialysis experiments were carried out in freely moving Wistar rats and in LepR-deficient Zucker rats (LepR

Indexed as

Administration, IntranasalAnimalsChromatography, High Pressure LiquidDopamineDose-Response Relationship, DrugExtracellular SpaceLeptinMaleMicrodialysisNeurotransmitter AgentsNucleus AccumbensRats, TransgenicRats, WistarRats, ZuckerReceptors, MelanocortinSerotoninDopamineLeptinNeurotransmitter AgentsReceptors, MelanocortinSerotoninDopamineLeptinMelanocortinNasal administrationNucleus accumbensSerotonin

Identifiers

PMID27412669
OpenAlexW2462368146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.