ReviewSchizophrenia bulletin2016
Engaging Research Domain Criteria (RDoC): Neurocircuitry in Search of Meaning.
Review in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Do Individuals With Overweight and Obesity Have Reduced Affective and Cognitive Empathy? A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Identifying behavioral and biological predictors of cannabis vapor self-administration in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Unique Challenges in Biomarkers for Psychotic Disorders.Brain sciences · 2024Article
- Application of Machine Learning to Sleep Stage Classification.Proceedings. International Conference on Computational Science and Computational Intelligence · 2021Article
- [Twelve years of research domain criteria in psychiatric research and practice: claim and reality].Der Nervenarzt · 2021Review
- Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia.Journal of neurodevelopmental disorders · 2020Article
- Research Domain Criteria: Strengths, Weaknesses, and Potential Alternatives for Future Psychiatric Research.Molecular neuropsychiatry · 2019Article
- Reproducibility of myelin content-based human habenula segmentation at 3 Tesla.Human brain mapping · 2018Article
- Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late "P300-Like" Event-Related Potential in Rats.Neural plasticity · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The Research Domain Criteria (RDoC) initiative was implemented to reorient the approach to mental health research from one focused on Diagnostic and Statistical Manual of Mental Disorders (DSM) nosology to one oriented to psychological constructs constrained by neurocircuitry and molecular entities. The initiative has generated significant discussion and valuable reflection on the moorings of psychiatric research. The purpose of this article is to illustrate how a basic or clinical investigator can engage RDoC to explore the neurobiological underpinnings of psychopathology and how a research question can be formulated in RDoC's framework. We utilize a brain region with significant growing interest, the habenula, as an example for probing RDoC's utility. Opportunities to enhance neurocircuitry-psychological construct associations and problems associated with neuronal populations that enable bidirectional circuitry influence are discussed. The exercise reveals areas for further development that could move RDoC from a promising research idea to a successfully engaged foundation for catalyzing clinically relevant discoveries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.