Evidence map›Paper›PMID 27412521›Full record

Trial reportBMC pediatrics2016

Pharmacokinetics of ranitidine in preterm and term neonates with gastroesophageal reflux.

Ismael Lares Asseff, Graciela Benitez Gaucin, Hugo Juárez Olguín, Jose Antonio Godinez Nájera, Alejandra Toledo López, Gabriela Pérez Guillé, Fausto Zamura Torres

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ismael Lares AsseffInterdisciplinary Centre of Investigation for Integral and Regional Development, Durango Unit, National Polytechnic Institute, Durango, Mexico.
Graciela Benitez GaucinPediatrics and Neonatology Services, General Hospital of Durango, Durango, Mexico.
Hugo Juárez OlguínLaboratory of Pharmacology, National Institute of Pediatrics, and Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico. juarezol@yahoo.com.
Jose Antonio Godinez NájeraInterdisciplinary Centre of Investigation for Integral and Regional Development, Durango Unit, National Polytechnic Institute, Durango, Mexico.
Alejandra Toledo LópezLaboratory of Pharmacology, National Institute of Pediatrics, and Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico.
Gabriela Pérez GuilléLaboratory of Pharmacology, National Institute of Pediatrics, and Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico.
Fausto Zamura TorresInterdisciplinary Centre of Investigation for Integral and Regional Development, Durango Unit, National Polytechnic Institute, Durango, Mexico.
Universidad Nacional Autónoma de México · MXInstituto Politécnico Nacional · MXDurango Institute of Technology · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to determine the effect of gestational age on pharmacokinetics of ranitidine in newborns with gastroesophageal reflux.

methodsA prospective, descriptive and pharmacokinetic study was carried out in 30 pre-term and 20 full-term babies. 3 mg/kg of ranitidine was administered intravenously to all the babies and at 0.25, 0.5, 1, 2, 4, and 8 h following the administration, samples of blood were drawn to assess ranitidine levels using high performance liquid chromatographic technique.

resultsPharmacokinetics of ranitidine had a bi-exponential behavior with a half-life elimination of (t1/2el) 2.79 h, area under curve (AUC) of 1688 ng/mL, volume of distribution (Vd) of 1.44 L/kg, and clearance (Cl) of 5.9 L/kg/h. The median plasmatic concentration in pre-terms was 1113 ng/mL and 280 ng/mL in full-terms. Vd, t1/2 and Cl presented high values in preterm although the correlation of Cl with glomerular filtration in term newborns was better.

conclusionsPlasma levels of ranitidine depend on the gestational age of the newborns. However, the possible relationship between after-birth age and pharmacokinetics of the neonates as their internal organs get matured without minding their gestational background.

Indexed as

Anti-Ulcer AgentsArea Under CurveChromatography, High Pressure LiquidFemaleGastroesophageal RefluxGestational AgeHalf-LifeHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInjections, IntravenousMaleProspective StudiesRanitidineAnti-Ulcer AgentsRanitidineFull-termGestational ageNeonatesPharmacokineticsPre-termRanitidine

Identifiers

PMID27412521
PMCPMC4944512
OpenAlexW2467056815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.