ArticleMolecular bioSystems2016
Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics.
Article in Molecular bioSystems, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Antioxidant and anti-inflammatory effects of bioactive peptides derived from whey protein using lactic acid bacteria.Food science of animal resources · 2026Article
- Integrating the milk microbiome signatures in mastitis: milk-omics and functional implications.World journal of microbiology & biotechnology · 2025Review
- Unveiling the power of proteomics in advancing tropical animal health and production.Tropical animal health and production · 2024Article
- Subclinical Mastitis fromJournal of agricultural and food chemistry · 2023Article
- Distinguishing Natural Infections of the Bovine Mammary Gland byAnimals : an open access journal from MDPI · 2023Article
- Diagnostic Screening of Bovine Mastitis Using MALDI-TOF MS Direct-Spotting of Milk and Machine Learning.Veterinary sciences · 2023Article
- Interrogating the role of the milk microbiome in mastitis in the multi-omics era.Frontiers in microbiology · 2023Review
- Metabolites in Milk after Enrofloxacin Treatment and Their Persistence to Temperature.Journal of agricultural and food chemistry · 2022Article
- Review
- Progress towards the Elusive Mastitis Vaccines.Vaccines · 2022Review
- LAP-MALDI MS coupled with machine learning: an ambient mass spectrometry approach for high-throughput diagnostics.Chemical science · 2022Article
- MALDI-TOF mass spectrometry profiling of bovine skim milk for subclinical mastitis detection.Frontiers in veterinary science · 2022Article
- Lycium barbarum polysaccharides alleviate LPS-induced inflammatory responses through PPARγ/MAPK/NF-κB pathway in bovine mammary epithelial cells.Journal of animal science · 2022Article
- Peptidomics and Capillary Electrophoresis.Advances in experimental medicine and biology · 2021Article
- Novel Biomarkers of Mastitis in Goat Milk Revealed by MALDI-TOF-MS-Based Peptide Profiling.Biology · 2020Article
- Enhanced Production of Galactooligosaccharides Enriched Skim Milk and Applied to Potentially Synbiotic Fermented Milk withFood science of animal resources · 2019Article
- Rapid changes in Atlantic grey seal milk from birth to weaning - immune factors and indicators of metabolic strain.Scientific reports · 2017Article
- Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics.Molecular bioSystems · 2016Article
- Serum Amyloid A and Lactoferrin Concentrations in Milk at Mastitis Diagnosis Can Serve as a Predictive Indicators of Intramammary Status 7 Days Later.Animal science journal = Nihon chikusan GakkaihoArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
A peptidomic investigation of milk from an experimental model of Streptococcus uberis mastitis in dairy cows has incorporated a study of milk high abundance and acute phase (APP) proteins as well as analysis of low molecular weight peptide biomarkers. Intramammary infection (IMI) with S. uberis caused a shift in abundance from caseins, β-lactoglobulin and α-lactalbumin to albumin, lactoferrin and IgG with the increase in lactoferrin occurring last. The APP response of haptoglobin, mammary associated serum amyloid A3 and C-reactive protein occurred between 30-48 hours post challenge with peak concentrations of APPs at 72-96 hours post challenge and declined thereafter at a rate resembling the fall in bacterial count rather than the somatic cell count. A peptide biomarker panel for IMI based on capillary electrophoresis and mass spectrometry was developed. It comprised 77 identified peptides (IMI77) composed mainly of casein derived peptides but also including peptides of glycosylation dependent cell adhesion molecule and serum amyloid A. The panel had a biomarker classification score that increased from 36 hour to 81 hour post challenge, significantly differentiating infected from non-infected milk, thus suggesting potential as a peptide biomarker panel of bovine mastitis and specifically that of S. uberis origin. The use of omic technology has shown a multifactorial cross system reaction in high and low abundance proteins and their peptide derivatives with changes of over a thousand fold in analyte levels in response to S. uberis infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.