ArticleScientific reports2016
Roles of OA1 octopamine receptor and Dop1 dopamine receptor in mediating appetitive and aversive reinforcement revealed by RNAi studies.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Octopamine Signaling Regulates Phototactic Behavior via a β-Adrenergic-like Receptor inInsects · 2026Article
- Independent operations of appetitive and aversive conditioning systems lead to simultaneous production of conflicting memories in an insect.Proceedings. Biological sciences · 2024Article
- Critical roles of nicotinic acetylcholine receptors in olfactory memory formation and retrieval in crickets.Frontiers in physiology · 2024Article
- Characterization and Localization of Sol g 2.1 Protein fromInternational journal of molecular sciences · 2023Article
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- Spontaneous recovery from overexpectation in an insect.Scientific reports · 2022Article
- Conditioned taste aversion in the cricket Gryllus bimaculatus.Scientific reports · 2022Article
- What Is Learned in Pavlovian Conditioning in Crickets? Revisiting the S-S and S-R Learning Theories.Frontiers in behavioral neuroscience · 2021Review
- Development of behavioural automaticity by extended Pavlovian training in an insect.Proceedings. Biological sciences · 2019Article
- Aversive gustatory learning and perception in honey bees.Scientific reports · 2018Article
- Application of a Prediction Error Theory to Pavlovian Conditioning in an Insect.Frontiers in psychology · 2018Article
- Signaling Pathways for Long-Term Memory Formation in the Cricket.Frontiers in psychology · 2018Review
- The Post-mating Switch in the Pheromone Response ofFrontiers in behavioral neuroscience · 2018Article
- Roles of dopamine neurons in mediating the prediction error in aversive learning in insects.Scientific reports · 2017Article
- Parallel memory traces are built after an experience containing aversive and appetitive components in the crabProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Roles of Octopamine and Dopamine Neurons for Mediating Appetitive and Aversive Signals in Pavlovian Conditioning in Crickets.Frontiers in physiology · 2017Review
- A decision underlies phototaxis in an insect.Open biology · 2016Article
- Interaction of inhibitory and facilitatory effects of conditioning trials on long-term memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Revealing reinforcing mechanisms in associative learning is important for elucidation of brain mechanisms of behavior. In mammals, dopamine neurons are thought to mediate both appetitive and aversive reinforcement signals. Studies using transgenic fruit-flies suggested that dopamine neurons mediate both appetitive and aversive reinforcements, through the Dop1 dopamine receptor, but our studies using octopamine and dopamine receptor antagonists and using Dop1 knockout crickets suggested that octopamine neurons mediate appetitive reinforcement and dopamine neurons mediate aversive reinforcement in associative learning in crickets. To fully resolve this issue, we examined the effects of silencing of expression of genes that code the OA1 octopamine receptor and Dop1 and Dop2 dopamine receptors by RNAi in crickets. OA1-silenced crickets exhibited impairment in appetitive learning with water but not in aversive learning with sodium chloride solution, while Dop1-silenced crickets exhibited impairment in aversive learning but not in appetitive learning. Dop2-silenced crickets showed normal scores in both appetitive learning and aversive learning. The results indicate that octopamine neurons mediate appetitive reinforcement via OA1 and that dopamine neurons mediate aversive reinforcement via Dop1 in crickets, providing decisive evidence that neurotransmitters and receptors that mediate appetitive reinforcement indeed differ among different species of insects.
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