Evidence map›Paper›PMID 27412389›Full record

ReviewBrain : a journal of neurology2016

Visual dysfunction in Parkinson's disease.

Rimona S Weil, Anette E Schrag, Jason D Warren, Sebastian J Crutch, Andrew J Lees, Huw R Morris

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain : a journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03137238 (Optic Flow and Vestibular Sensory Integration in Self-motion Perception in Parkinson's Disease), which is not on this map. Cited by 209 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 4 pooled it
23.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03137238 unknown statusnot on this mapstarted 2017, after this paper: background citation

Optic Flow and Vestibular Sensory Integration in Self-motion Perception in Parkinson's Disease

TypeobservationalSponsorSheba Medical CenterRan2017 to 2022Enrolled100ConditionsParkinson DiseaseArmsInvestigation of self-perception in Parkinson's disease
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 4 syntheses or guidelines pooled it, 464 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Contrast Sensitivity Function in Parkinson's Disease: Effects of Illumination and Disease Stage.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Article

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rimona S WeilInstitute of Neurology, University College London, London, UK.
Anette E SchragInstitute of Neurology, University College London, London, UK.
Jason D WarrenNational Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Sebastian J CrutchDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Andrew J LeesInstitute of Neurology, University College London, London, UK.
Huw R MorrisInstitute of Neurology, University College London, London, UK.
National Hospital for Neurology and Neurosurgery · GBUniversity College London · GB

Funding

Department of Health [UK]Medical Research Council G0700943Medical Research Council G1100643Parkinson's UK J-0804Parkinson's UK K-1501
6 · The paper itself

Abstract

Patients with Parkinson's disease have a number of specific visual disturbances. These include changes in colour vision and contrast sensitivity and difficulties with complex visual tasks such as mental rotation and emotion recognition. We review changes in visual function at each stage of visual processing from retinal deficits, including contrast sensitivity and colour vision deficits to higher cortical processing impairments such as object and motion processing and neglect. We consider changes in visual function in patients with common Parkinson's disease-associated genetic mutations including GBA and LRRK2 . We discuss the association between visual deficits and clinical features of Parkinson's disease such as rapid eye movement sleep behavioural disorder and the postural instability and gait disorder phenotype. We review the link between abnormal visual function and visual hallucinations, considering current models for mechanisms of visual hallucinations. Finally, we discuss the role of visuo-perceptual testing as a biomarker of disease and predictor of dementia in Parkinson's disease.

Indexed as

beta-GlucosidaseHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseVision DisordersVisual PathwaysVisual Perceptionbeta-GlucosidaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2cognitionParkinson’s diseaseperceptionvision

Identifiers

PMID27412389
PMCPMC5091042
OpenAlexW2474900144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.