ArticleScientific reports2016
How Escherichia coli lands and forms cell clusters on a surface: a new role of surface topography.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 76 citations in OpenAlex.
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- Antimicrobial Surfaces for Reusable Food Packaging: A Comprehensive Review of Functionality and Suitability.Comprehensive reviews in food science and food safety · 2026Review
- Vancomycin-Mediated Binding of DNA Origami Nanostructures to Gram-Positive and Gram-Negative Bacteria.Chembiochem : a European journal of chemical biology · 2026Article
- Dynamically actuated reconfigurable topographical surface enables active control of implant-associated infections.bioRxiv : the preprint server for biology · 2026Article
- Emerging non-antibiotic strategies for implant-associated biofilm infections by reprogramming the dysregulated immune microenvironment.NPJ biofilms and microbiomes · 2026Review
- Engineering multifunctional surface topography to regulate multiple biological responses.Biomaterials · 2025Review
- Harnessing Biofilm-Mediated Plastic Biodegradation: Innovating Smart Material Design.ACS applied engineering materials · 2025Review
- Human mesofluidic intestinal model for studying transport of drug carriers and bacteria through a live mucosal barrier.Lab on a chip · 2025Article
- Advanced Strategies for Enhancing the Biocompatibility and Antibacterial Properties of Implantable Structures.Materials (Basel, Switzerland) · 2025Review
- Advancements in Polymer Biomaterials as Scaffolds for Corneal Endothelium Tissue Engineering.Polymers · 2024Review
- Metabolic interactions shape emergent biofilm structures in a conceptual model of gut mucosal bacterial communities.NPJ biofilms and microbiomes · 2024Article
- The direct inhibitory effects of Lactobacillus acidophilus, a commensal urinary bacterium, on calcium oxalate stone development.Microbiome · 2024Article
- Microfluidic Platform with Precisely Controlled Hydrodynamic Parameters and Integrated Features for Generation of Microvortices to Accurately Form and Monitor Biofilms in Flow.ACS biomaterials science & engineering · 2024Article
- Application of Membrane Filtration to Cold Sterilization of Drinks and Establishment of Aseptic Workshop.Food and environmental virology · 2023Review
- Microplastics detected in cirrhotic liver tissue.EBioMedicine · 2022Article
- Surface Texturing and Combinatorial Approaches to Improve Biocompatibility of Implanted Biomaterials.Frontiers in physics · 2022Article
- Manipulating Bacterial Biofilms Using Materiobiology and Synthetic Biology Approaches.Frontiers in microbiology · 2022Review
- Bacterial adhesion to biomaterials: What regulates this attachment? A review.The Japanese dental science review · 2021Review
- Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Image-based cell subpopulation identification through automated cell tracking, principal component analysis, and partitioning around medoids clustering.Medical & biological engineering & computing · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial response to surface topography during biofilm formation was studied using 5 μm tall line patterns of poly (dimethylsiloxane) (PDMS). Escherichia coli cells attached on top of protruding line patterns were found to align more perpendicularly to the orientation of line patterns when the pattern narrowed. Consistently, cell cluster formation per unit area on 5 μm wide line patterns was reduced by 14-fold compared to flat PDMS. Contrasting the reduced colony formation, cells attached on narrow patterns were longer and had higher transcriptional activities, suggesting that such unfavorable topography may present a stress to attached cells. Results of mutant studies indicate that flagellar motility is involved in the observed preference in cell orientation on narrow patterns, which was corroborated by the changes in cell rotation pattern before settling on different surface topographies. These findings led to a set of new design principles for creating antifouling topographies, which was validated using 10 μm tall hexagonal patterns.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.